3UX4

Crystal structure of the urea channel from the human gastric pathogen Helicobacter pylori

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	AmiS/UreI transporter-like	8050075	4006760	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Succinate-acetate permease SatP-like	8095817	3002706	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Succinate-acetate permease SatP-like	8095817	3002706	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Succinate-acetate permease SatP-like	8095817	3002706	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02293	e3ux4A1	A: alpha complex topology	X: Acid-activated urea channel (From Topology)	H: Acid-activated urea channel (From Topology)	T: Acid-activated urea channel	F: PF02293	ECOD (1.6)
B	PF02293	e3ux4B1	A: alpha complex topology	X: Acid-activated urea channel (From Topology)	H: Acid-activated urea channel (From Topology)	T: Acid-activated urea channel	F: PF02293	ECOD (1.6)
C	PF02293	e3ux4C1	A: alpha complex topology	X: Acid-activated urea channel (From Topology)	H: Acid-activated urea channel (From Topology)	T: Acid-activated urea channel	F: PF02293	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.600	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	AmiS/UreI transporter	CATH (4.3.0)
B	1.25.40.600	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	AmiS/UreI transporter	CATH (4.3.0)
C	1.25.40.600	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	AmiS/UreI transporter	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF02293	AmiS/UreI family transporter (AmiS_UreI)	AmiS/UreI family transporter	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Acid-activated urea channel	identical protein binding protein binding binding	-	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR003211	AmiS/UreI transporter	Family
A, B, C	IPR038523	AmiS/UreI transporter superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM				Urea/amide channel

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Urea Transporters	UreI proton-gated inner membrane urea channel

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.