3TSR

X-ray structure of mouse ribonuclease inhibitor complexed with mouse ribonuclease 1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3tsra_	Alpha and beta proteins (a+b)	RNase A-like	RNase A-like	Ribonuclease A-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d3tsrb_	Alpha and beta proteins (a+b)	RNase A-like	RNase A-like	Ribonuclease A-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d3tsrc_	Alpha and beta proteins (a+b)	RNase A-like	RNase A-like	Ribonuclease A-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d3tsrd_	Alpha and beta proteins (a+b)	RNase A-like	RNase A-like	Ribonuclease A-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d3tsre1	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	RNI-like	28-residue LRR	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d3tsre2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F	d3tsrf1	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	RNI-like	28-residue LRR	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F	d3tsrf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d3tsrg1	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	RNI-like	28-residue LRR	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d3tsrg2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H	d3tsrh1	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	RNI-like	28-residue LRR	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H	d3tsrh2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ribonuclease A-like	8069358	4000894	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RNase A-like	8069359	3001918	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	RNase A-like	8069359	3001918	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RNase A-like	8069359	3001918	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RNase A-like	8069359	3001918	SCOP2B (2022-06-29)
E	SCOP2 Family	28-residue LRR	8076669	4003523	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	RNI-like	8076670	3000990	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	RNI-like	8076670	3000990	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	RNI-like	8076670	3000990	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	RNI-like	8076670	3000990	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RNAse_Pc_like	e3tsrA1	A: a+b complex topology	X: RNase A-like	H: RNase A-like (From Topology)	T: RNase A-like	F: RNAse_Pc_like	ECOD (1.6)
B	RNAse_Pc_like	e3tsrB1	A: a+b complex topology	X: RNase A-like	H: RNase A-like (From Topology)	T: RNase A-like	F: RNAse_Pc_like	ECOD (1.6)
C	RNAse_Pc_like	e3tsrC1	A: a+b complex topology	X: RNase A-like	H: RNase A-like (From Topology)	T: RNase A-like	F: RNAse_Pc_like	ECOD (1.6)
D	RNAse_Pc_like	e3tsrD1	A: a+b complex topology	X: RNase A-like	H: RNase A-like (From Topology)	T: RNase A-like	F: RNAse_Pc_like	ECOD (1.6)
E	LRR_8_4	e3tsrE1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_4	ECOD (1.6)
F	LRR_8_4	e3tsrF1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_4	ECOD (1.6)
G	LRR_8_4	e3tsrG1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_4	ECOD (1.6)
H	LRR_8_4	e3tsrH1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.130.10	Alpha Beta	Roll	P-30 Protein	Ribonuclease A-like domain	CATH (4.3.0)
B	3.10.130.10	Alpha Beta	Roll	P-30 Protein	Ribonuclease A-like domain	CATH (4.3.0)
C	3.10.130.10	Alpha Beta	Roll	P-30 Protein	Ribonuclease A-like domain	CATH (4.3.0)
D	3.10.130.10	Alpha Beta	Roll	P-30 Protein	Ribonuclease A-like domain	CATH (4.3.0)
E	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
F	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
G	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
H	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00074	Pancreatic ribonuclease (RnaseA)	Pancreatic ribonuclease	Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.	Domain
E, F, G, H	PF13516	Leucine Rich repeat (LRR_6)	Leucine Rich repeat	-	Repeat
E, F, G, H	PF18779	Capping Ribonuclease inhibitor Leucine Rich Repeat (LRR_RI_capping)	Capping Ribonuclease inhibitor Leucine Rich Repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Ribonuclease pancreatic	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters endonuclease activity ribonuclease A activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity RNA endonuclease activity, producing 3'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity catalytic activity lyase activity binding endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters endonuclease activity ribonuclease A activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity RNA endonuclease activity, producing 3'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity catalytic activity lyase activity binding organic cyclic compound binding nucleic acid binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus defense response defense response to Gram-positive bacterium defense response to bacterium defense response to other organism response to stress	extracellular region cellular anatomical entity
E, F, G, H	Ribonuclease inhibitor	enzyme regulator activity molecular function inhibitor activity molecular function regulator activity nuclease inhibitor activity enzyme inhibitor activity ribonuclease inhibitor activity	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis regulation of angiogenesis anatomical structure development anatomical structure formation involved in morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process cellular component organization regulation of actin nucleation actin filament-based process cellular component organization or biogenesis regulation of actin filament organization actin cytoskeleton organization actin filament organization Arp2/3 complex-mediated actin nucleation regulation of organelle organization organelle organization regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process actin nucleation supramolecular fiber organization cytoskeleton organization cell migration cell motility	protein-containing complex extracellular region angiogenin-PRI complex cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery plasma membrane membrane protein-containing complex extracellular region angiogenin-PRI complex cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell projection cell leading edge plasma membrane bounded cell projection lamellipodium cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR023412	Ribonuclease A-domain	Domain
A, B, C, D	IPR036816	Ribonuclease A-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR001427	Pancreatic ribonuclease	Family
A, B, C, D	IPR023411	Ribonuclease A, active site	Active Site
E, F, G, H	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
E, F, G, H	IPR041302	Ribonuclease inhibitor, leucine rich repeat cap	Repeat
E, F, G, H	IPR001611	Leucine-rich repeat	Repeat

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.