3TIX

Crystal structure of the Chp1-Tas3 complex core

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ubiquitin-like	8034468	3000157	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ubiquitin-like	8034468	3000157	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22378	e3tixA1	A: alpha bundles	X: Tas3 N-terminal domain (From Topology)	H: Tas3 N-terminal domain (From Topology)	T: Tas3 N-terminal domain	F: PF22378	ECOD (1.6)
A	PF11976	e3tixA2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF11976	ECOD (1.6)
C	PF22378	e3tixC1	A: alpha bundles	X: Tas3 N-terminal domain (From Topology)	H: Tas3 N-terminal domain (From Topology)	T: Tas3 N-terminal domain	F: PF22378	ECOD (1.6)
C	PF11976	e3tixC2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF11976	ECOD (1.6)
B	PF22380	e3tixB2	A: beta barrels	X: SPOC domain-like	H: SPOC domain-related	T: SPOC domain	F: PF22380	ECOD (1.6)
B	PF21484	e3tixB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PF21484	ECOD (1.6)
B	F_UNCLASSIFIED	e3tixB3	A: a/b three-layered sandwiches	X: Chromo domain-containing protein 1 (Chp1) domain II (From Topology)	H: Chromo domain-containing protein 1 (Chp1) domain II (From Topology)	T: Chromo domain-containing protein 1 (Chp1) domain II	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF22380	e3tixD1	A: beta barrels	X: SPOC domain-like	H: SPOC domain-related	T: SPOC domain	F: PF22380	ECOD (1.6)
D	PF21484	e3tixD3	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PF21484	ECOD (1.6)
D	F_UNCLASSIFIED	e3tixD2	A: a/b three-layered sandwiches	X: Chromo domain-containing protein 1 (Chp1) domain II (From Topology)	H: Chromo domain-containing protein 1 (Chp1) domain II (From Topology)	T: Chromo domain-containing protein 1 (Chp1) domain II	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
A	6.10.140.1690	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
C	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
C	6.10.140.1690	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
B	2.40.290.20	Mainly Beta	Beta Barrel	Ku70	Chain: A	CATH (4.3.0)
B	3.40.1010.30	Alpha Beta	3-Layer(aba) Sandwich	Cobalt-precorrin-4 Transmethylase	domain 1	CATH (4.3.0)
B	3.40.50.11490	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	2.40.290.20	Mainly Beta	Beta Barrel	Ku70	Chain: A	CATH (4.3.0)
D	3.40.1010.30	Alpha Beta	3-Layer(aba) Sandwich	Cobalt-precorrin-4 Transmethylase	domain 1	CATH (4.3.0)
D	3.40.50.11490	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF21484	Chromo domain-containing protein 1-like, PIN domain (Chp1-like_PIN)	Chromo domain-containing protein 1-like, PIN domain	This domain is found at the C-terminal end of Chromo domain- containing protein 1 from Schizosaccharomyces pombe (Chp1) and similar proteins predominantly found in yeast. Chp1 is a component of the RNA-induced initiation of Transcriptional Gene Silen ...	This domain is found at the C-terminal end of Chromo domain- containing protein 1 from Schizosaccharomyces pombe (Chp1) and similar proteins predominantly found in yeast. Chp1 is a component of the RNA-induced initiation of Transcriptional Gene Silencing (RITS) complex, a central player RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. This entry represents the PIN domain of Chp1, which shows an alpha-beta fold [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Ubiquitin-like protein SMT3,RNA-induced transcriptional silencing complex protein tas3	molecular adaptor activity protein tag activity molecular tag activity protein binding binding ubiquitin-like protein ligase binding enzyme binding identical protein binding	regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process cell cycle chromosome segregation cell cycle process siRNA-mediated pericentric heterochromatin formation regulatory ncRNA-mediated gene silencing pericentric heterochromatin formation constitutive heterochromatin formation regulatory ncRNA-mediated heterochromatin formation silent mating-type cassette heterochromatin formation organonitrogen compound metabolic process peptidyl-lysine modification primary metabolic process protein sumoylation macromolecule modification peptidyl-amino acid modification protein metabolic process protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal	intracellular organelle microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle spindle pole body cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex nucleus membrane-enclosed lumen intracellular organelle microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle spindle pole body cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome heterochromatin RNAi effector complex intracellular organelle lumen RITS complex protein-DNA complex chromatin intracellular membrane-bounded organelle organelle lumen ribonucleoprotein complex nuclear lumen mating-type region heterochromatin cytoplasm chromosome, subtelomeric region chromosome, telomeric region chromosomal region pericentric heterochromatin chromosome, centromeric region cell cortex septin ring cell periphery septin cytoskeleton condensed nuclear chromosome condensed chromosome
B, D	Chromo domain-containing protein 1	protein binding binding histone binding protein-containing complex binding chromatin binding RNA binding organic cyclic compound binding nucleic acid binding single-stranded RNA binding DNA binding histone reader activity chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding histone binding protein-containing complex binding chromatin binding RNA binding organic cyclic compound binding nucleic acid binding single-stranded RNA binding DNA binding histone reader activity chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity methylated histone binding modification-dependent protein binding methylation-dependent protein binding	cellular process cell cycle chromosome segregation cell cycle process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process cellular process cell cycle chromosome segregation cell cycle process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation siRNA-mediated pericentric heterochromatin formation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulatory ncRNA-mediated gene silencing pericentric heterochromatin formation regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process regulatory ncRNA-mediated heterochromatin formation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process subtelomeric heterochromatin formation telomere organization chromosome organization organelle organization regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II primary metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process	protein-containing complex intracellular anatomical structure protein-DNA complex heterochromatin island chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle mating-type region heterochromatin cytoplasm protein-containing complex intracellular anatomical structure protein-DNA complex heterochromatin island chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle mating-type region heterochromatin cytoplasm chromosome, subtelomeric region chromosome, telomeric region chromosomal region pericentric heterochromatin chromosome, centromeric region microtubule organizing center cytoskeleton spindle pole body microtubule cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome RNAi effector complex intracellular organelle lumen RITS complex intracellular membrane-bounded organelle organelle lumen ribonucleoprotein complex nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR049112	Tas3, C-terminal helical domain	Domain
A, C	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A, C	IPR000626	Ubiquitin-like domain	Domain
A, C	IPR022617	Rad60/SUMO-like domain	Domain
B, D	IPR048709	Chop1, PIN domain	Domain
B, D	IPR023780	Chromo domain	Domain
B, D	IPR016197	Chromo-like domain superfamily	Homologous Superfamily
B, D	IPR023779	Chromo domain, conserved site	Conserved Site
B, D	IPR000953	Chromo/chromo shadow domain	Domain
B, D	IPR035979	RNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.