3TG0

E. coli alkaline phosphatase with bound inorganic phosphate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3tg0a_	Alpha and beta proteins (a/b)	Alkaline phosphatase-like	Alkaline phosphatase-like	Alkaline phosphatase	Alkaline phosphatase	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d3tg0b_	Alpha and beta proteins (a/b)	Alkaline phosphatase-like	Alkaline phosphatase-like	Alkaline phosphatase	Alkaline phosphatase	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d3tg0c_	Alpha and beta proteins (a/b)	Alkaline phosphatase-like	Alkaline phosphatase-like	Alkaline phosphatase	Alkaline phosphatase	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d3tg0d_	Alpha and beta proteins (a/b)	Alkaline phosphatase-like	Alkaline phosphatase-like	Alkaline phosphatase	Alkaline phosphatase	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Alkaline phosphatase-like	8034139	3001353	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Alkaline phosphatase-like	8034139	3001353	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Alkaline phosphatase-like	8034139	3001353	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Alkaline phosphatase-like	8034139	3001353	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00245	e3tg0A1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00245	ECOD (1.6)
B	PF00245	e3tg0B1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00245	ECOD (1.6)
C	PF00245	e3tg0C1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00245	ECOD (1.6)
D	PF00245	e3tg0D1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00245	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	CATH (4.3.0)
B	3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	CATH (4.3.0)
C	3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	CATH (4.3.0)
D	3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00245	Alkaline phosphatase (Alk_phosphatase)	Alkaline phosphatase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Alkaline phosphatase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding oxidoreductase activity catalytic activity oxidoreductase activity, acting on phosphorus or arsenic in donors phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding oxidoreductase activity catalytic activity oxidoreductase activity, acting on phosphorus or arsenic in donors phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity hydrogenase (acceptor) activity oxidoreductase activity, acting on hydrogen as donor transition metal ion binding zinc ion binding alkaline phosphatase activity	protein dephosphorylation organonitrogen compound metabolic process dephosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process	periplasmic space cellular anatomical entity outer membrane-bounded periplasmic space cell envelope

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR018299	Alkaline phosphatase, active site	Active Site
A, B, C, D	IPR001952	Alkaline phosphatase	Family
A, B, C, D	IPR017850	Alkaline-phosphatase-like, core domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.