3T8S
Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | PF02815 | e3t8sB18 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF02815 | ECOD (1.6) |
B | PF08709 | e3t8sB16 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF08709 | ECOD (1.6) |
B | PF01365 | e3t8sB17 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PF01365 | ECOD (1.6) |
A | PF02815 | e3t8sA15 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF02815 | ECOD (1.6) |
A | PF08709 | e3t8sA13 | A: beta duplicates or obligate multimers | X: beta-Trefoil (From Topology) | H: beta-Trefoil (From Topology) | T: beta-Trefoil | F: PF08709 | ECOD (1.6) |
A | PF01365 | e3t8sA14 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PF01365 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 2.80.10.50 | Mainly Beta | Trefoil | Trefoil (Acidic Fibroblast Growth Factor, subunit A) | CATH (4.3.0) | |
B | 1.25.10.30 | Mainly Alpha | Alpha Horseshoe | Leucine-rich Repeat Variant | IP3 receptor type 1 binding core, RIH domain | CATH (4.3.0) |
A | 2.80.10.50 | Mainly Beta | Trefoil | Trefoil (Acidic Fibroblast Growth Factor, subunit A) | CATH (4.3.0) | |
A | 1.25.10.30 | Mainly Alpha | Alpha Horseshoe | Leucine-rich Repeat Variant | IP3 receptor type 1 binding core, RIH domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02815 | MIR domain (MIR) | MIR domain | The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function [1]. | Domain | |
PF08709 | Inositol 1,4,5-trisphosphate/ryanodine receptor (Ins145_P3_rec) | Inositol 1,4,5-trisphosphate/ryanodine receptor | This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-ga ... | Domain | |
PF01365 | RIH domain (RYDR_ITPR) | RIH domain | - | Repeat |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR036300 | Mir domain superfamily | Homologous Superfamily | |
IPR000699 | RIH domain | Domain | |
IPR016024 | Armadillo-type fold | Homologous Superfamily | |
IPR013662 | RyR/IP3R Homology associated domain | Domain | |
IPR016093 | MIR motif | Domain | |
IPR015925 | Ryanodine/Inositol 1,4,5-trisphosphate receptor | Family | |
IPR035910 | RyR/IP3 receptor binding core, RIH domain superfamily | Homologous Superfamily | |
IPR014821 | Inositol 1,4,5-trisphosphate/ryanodine receptor | Domain | |
IPR000493 | Inositol 1,4,5-trisphosphate receptor | Family | |
IPR005821 | Ion transport domain | Domain |