3T6P

IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Inhibitor of apoptosis (IAP) repeat	8040576	3001510	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21290	e3t6pA3	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: PF21290	ECOD (1.6)
A	PF00619	e3t6pA4	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: PF00619	ECOD (1.6)
A	PF13920	e3t6pA2	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF13920	ECOD (1.6)
A	PF00653	e3t6pA1	A: few secondary structure elements	X: Inhibitor of apoptosis (IAP) repeat (From Topology)	H: Inhibitor of apoptosis (IAP) repeat (From Topology)	T: Inhibitor of apoptosis (IAP) repeat	F: PF00653	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1170.10	Mainly Alpha	Orthogonal Bundle	Inhibitor Of Apoptosis Protein (2mihbC-IAP-1)	Chain A	CATH (4.3.0)
A	1.10.8.10	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
A	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00619	Caspase recruitment domain (CARD)	Caspase recruitment domain	Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (Pfam:PF00531) domain-like fold .	Domain
A	PF21290	BIRC2/3-like, UBA domain (BIRC2-3-like_UBA)	BIRC2/3-like, UBA domain	Baculoviral IAP repeat-containing proteins, also known as c-IAPs, function as ubiquitin E3 ligases that mediate the ubiquitination of the substrates involved in apoptosis, nuclear factor-kappaB (NF-kappaB) signaling, and oncogenesis [1-3]. This entry ...	Baculoviral IAP repeat-containing proteins, also known as c-IAPs, function as ubiquitin E3 ligases that mediate the ubiquitination of the substrates involved in apoptosis, nuclear factor-kappaB (NF-kappaB) signaling, and oncogenesis [1-3]. This entry represents the UBA domain of BIRC2/3/4/8 from mammals and BIRC7 from Xenopus tropicalis [1-3].	Domain
A	PF00653	Inhibitor of Apoptosis domain (BIR)	Inhibitor of Apoptosis domain	BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, incl ...	BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin (Swiss:O15392) [2].	Domain
A	PF13920	Zinc finger, C3HC4 type (RING finger) (zf-C3HC4_3)	Zinc finger, C3HC4 type (RING finger)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Baculoviral IAP repeat-containing protein 2	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding protein-folding chaperone binding protein-containing complex binding identical protein binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding protein-folding chaperone binding protein-containing complex binding identical protein binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity ubiquitin binding ubiquitin-like protein binding enzyme regulator activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process molecular function regulator activity cysteine-type endopeptidase regulator activity involved in apoptotic process FBXO family protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process placenta development animal organ development anatomical structure development cellular process apoptotic process cell death programmed cell death regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation regulation of programmed cell death cellular response to stimulus developmental process placenta development animal organ development anatomical structure development cellular process apoptotic process cell death programmed cell death regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation regulation of programmed cell death cellular response to stimulus response to stimulus signaling non-canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway toll-like receptor signaling pathway regulation of signal transduction response to biotic stimulus immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus regulation of response to stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response regulation of toll-like receptor signaling pathway activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response response to external biotic stimulus regulation of signaling positive regulation of innate immune response defense response defense response to symbiont immune system process regulation of cell communication organonitrogen compound metabolic process protein polyubiquitination primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal necroptotic process programmed necrotic cell death regulation of necroptotic process regulation of programmed necrotic cell death response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus response to organic substance cell surface receptor signaling pathway response to cytokine cytokine-mediated signaling pathway cellular response to chemical stimulus cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus cellular response to organic substance response to tumor necrosis factor regulation of protein modification process positive regulation of protein metabolic process regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process positive regulation of macromolecule metabolic process regulation of protein modification by small protein conjugation or removal positive regulation of protein monoubiquitination positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification regulation of protein metabolic process regulation of macromolecule metabolic process protein monoubiquitination regulation of protein monoubiquitination regulation of metabolic process protein K63-linked ubiquitination regulation of protein K63-linked ubiquitination positive regulation of protein K63-linked ubiquitination regulation of protein polyubiquitination positive regulation of protein polyubiquitination response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP response to organic cyclic compound regulation of cysteine-type endopeptidase activity regulation of catalytic activity regulation of peptidase activity regulation of molecular function regulation of proteolysis proteolysis regulation of hydrolase activity regulation of endopeptidase activity regulation of cellular component organization negative regulation of biological process ripoptosome assembly cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly negative regulation of cellular process negative regulation of ripoptosome assembly involved in necroptotic process cellular component organization or biogenesis negative regulation of cellular component organization protein-containing complex organization ripoptosome assembly involved in necroptotic process regulation of cellular component biogenesis negative regulation of protein-containing complex assembly regulation of ripoptosome assembly involved in necroptotic process positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction regulation of intracellular signal transduction positive regulation of cellular process positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of signaling cytoplasmic pattern recognition receptor signaling pathway intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway negative regulation of programmed cell death negative regulation of apoptotic process positive regulation of protein K48-linked ubiquitination regulation of protein K48-linked ubiquitination protein K48-linked ubiquitination organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of non-canonical NF-kappaB signal transduction response to alcohol response to ethanol negative regulation of necroptotic process negative regulation of programmed necrotic cell death regulation of RIG-I signaling pathway RIG-I signaling pathway regulation of inflammatory response inflammatory response cell population proliferation regulation of cell population proliferation cell cycle regulation of cell cycle cellular metabolic process reactive oxygen species metabolic process regulation of cellular metabolic process regulation of reactive oxygen species metabolic process regulation of developmental process cellular developmental process cell differentiation regulation of cell differentiation	cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex CD40 receptor complex cellular anatomical entity receptor complex intracellular anatomical structure cytoplasm cytosol intracellular organelle cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex CD40 receptor complex cellular anatomical entity receptor complex intracellular anatomical structure cytoplasm cytosol intracellular organelle XY body sex chromosome organelle intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR048875	BIRC2/3-like, UBA domain	Domain
A	IPR001370	BIR repeat	Repeat
A	IPR001841	Zinc finger, RING-type	Domain
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR041933	BIRC2/BIRC3, UBA domain	Domain
A	IPR001315	CARD domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13490	leukemia breast carcinoma HIV infectious disease breast cancer gastric cancer HIV Coinfection plasma cell myeloma gastric neoplasm psoriasis dermatomyositis hereditary diffuse gastric adenocarcinoma juvenile dermatomyositis ovarian cancer tuberculosis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.