3SZ7

Crystal structure of the Sgt2 TPR domain from Aspergillus fumigatus

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TPR_11_5	e3sz7A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
A	PF13414	TPR repeat (TPR_11)	TPR repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Hsc70 cochaperone (SGT)	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds myosin phosphatase activity phosphatase activity hydrolase activity catalytic activity molecular adaptor activity identical protein binding protein binding binding	protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting post-translational protein targeting to endoplasmic reticulum membrane localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting post-translational protein targeting to endoplasmic reticulum membrane localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle cellular process establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER response to stimulus response to stress response to heat response to abiotic stimulus response to temperature stimulus	protein-containing complex intracellular anatomical structure TRC complex cytoplasm cellular anatomical entity ER membrane insertion complex cytosol membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR047150	SGT	Family
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR019734	Tetratricopeptide repeat	Repeat
A	IPR032374	SGTA, homodimerisation domain	Domain
A	IPR006636	Heat shock chaperonin-binding	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.