Annotations: 3SXU

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3sxua_	Alpha and beta proteins (a/b)	DNA polymerase III chi subunit	DNA polymerase III chi subunit	DNA polymerase III chi subunit	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DNA polymerase III chi subunit	8035680	3000660	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	DNA polymerase III psi subunit	8035684	3000417	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DNA_pol3_chi	e3sxuA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DNA_pol3_chi	ECOD (1.6)
B	DNA_III_psi	e3sxuB1	A: a/b three-layered sandwiches	X: DNA polymerase III psi subunit (From Topology)	H: DNA polymerase III psi subunit (From Topology)	T: DNA polymerase III psi subunit	F: DNA_III_psi	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10110	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	DNA polymerase III subunit chi	CATH (4.3.0)
B	3.40.50.10220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	DNA polymerase III, psi subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04364	DNA polymerase III chi subunit, HolC (DNA_pol3_chi)	DNA polymerase III chi subunit, HolC	-	Family
B	PF03603	DNA polymerase III psi subunit (DNA_III_psi)	DNA polymerase III psi subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA polymerase III subunit chi	catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups DNA binding binding organic cyclic compound binding nucleic acid binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process response to stimulus response to radiation response to abiotic stimulus regulation of DNA-templated DNA replication initiation positive regulation of DNA replication nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process response to stimulus response to radiation response to abiotic stimulus regulation of DNA-templated DNA replication initiation positive regulation of DNA replication positive regulation of biological process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process DNA-templated DNA replication regulation of biological process positive regulation of nucleobase-containing compound metabolic process DNA replication initiation biological regulation regulation of macromolecule metabolic process positive regulation of DNA metabolic process regulation of DNA-templated DNA replication positive regulation of DNA-templated DNA replication regulation of metabolic process positive regulation of DNA-templated DNA replication initiation regulation of DNA replication regulation of DNA metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle cellular anatomical entity DNA polymerase complex transferase complex, transferring phosphorus-containing groups intracellular organelle DNA polymerase III complex organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle cellular anatomical entity DNA polymerase complex transferase complex, transferring phosphorus-containing groups intracellular organelle DNA polymerase III complex organelle DNA polymerase III, clamp loader complex intracellular protein-containing complex protein-DNA complex chromosome intracellular non-membrane-bounded organelle replication fork replisome non-membrane-bounded organelle
B	DNA polymerase III subunit psi	catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups nuclease activity hydrolase activity, acting on ester bonds 3'-5' exonuclease activity hydrolase activity exonuclease activity	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process response to stimulus response to radiation response to abiotic stimulus DNA-templated DNA replication	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle cellular anatomical entity DNA polymerase complex transferase complex, transferring phosphorus-containing groups intracellular organelle DNA polymerase III complex organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex transferase complex intracellular membrane-bounded organelle cellular anatomical entity DNA polymerase complex transferase complex, transferring phosphorus-containing groups intracellular organelle DNA polymerase III complex organelle DNA polymerase III, clamp loader complex intracellular protein-containing complex protein-DNA complex chromosome intracellular non-membrane-bounded organelle replication fork replisome non-membrane-bounded organelle
C	SSB peptide	enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity identical protein binding protein binding binding DNA binding organic cyclic compound binding single-stranded DNA binding nucleic acid binding	cellular response to stimulus mismatch repair response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process cellular response to stimulus mismatch repair response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair DNA-templated DNA replication DNA replication DNA recombination recombinational repair positive regulation of molecular function regulation of molecular function regulation of catalytic activity biological regulation positive regulation of catalytic activity SOS response	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex nucleoid single-stranded DNA-binding protein complex protein-DNA complex chromosome intracellular organelle organelle intracellular non-membrane-bounded organelle replication fork replisome intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex nucleoid single-stranded DNA-binding protein complex protein-DNA complex chromosome intracellular organelle organelle intracellular non-membrane-bounded organelle replication fork replisome non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007459	DNA polymerase III chi subunit, HolC	Family
A	IPR036768	DNA polymerase III subunit chi superfamily	Homologous Superfamily
B	IPR018382	DNA polymerase III, psi subunit, subgroup	Family
B	IPR036654	DNA polymerase III, psi subunit superfamily	Homologous Superfamily
B	IPR004615	DNA polymerase III, psi subunit	Family
C	IPR011344	Single-stranded DNA-binding protein	Family
C	IPR000424	Primosome PriB/single-strand DNA-binding	Family
C	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.