3SWV

Crystal Structure of a domain of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) from Homo sapiens (Human), Northeast Structural Genomics Consortium target id HR5562A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3swva_	All alpha proteins	alpha-alpha superhelix	Sec7 domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sec7 domain-like	8080824	3001279	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01369	e3swvA1	A: alpha arrays	X: Sec7 domain (From Topology)	H: Sec7 domain (From Topology)	T: Sec7 domain	F: PF01369	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.220.20	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
A	1.10.1000.11	Mainly Alpha	Orthogonal Bundle	Arf Nucleotide-binding Site Opener	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01369	Sec7 domain (Sec7)	Sec7 domain	The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the Pfam:PF00025 family [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Brefeldin A-inhibited guanine nucleotide-exchange protein 2	protein binding binding signaling receptor binding GABA receptor binding protein kinase A binding protein kinase A regulatory subunit binding cytoskeletal protein binding myosin binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	organic substance metabolic process receptor metabolic process metabolic process macromolecule metabolic process receptor recycling Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization organic substance metabolic process receptor metabolic process metabolic process macromolecule metabolic process receptor recycling Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization cellular process Golgi vesicle transport protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization cellular component organization cellular component organization or biogenesis endomembrane system organization cellular response to stimulus regulation of biological process regulation of signaling small GTPase-mediated signal transduction regulation of cellular process response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation ARF protein signal transduction regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of ARF protein signal transduction intracellular signaling cassette regulation of cell communication signal transduction multicellular organismal process regulation of tumor necrosis factor production cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of biosynthetic process cytokine production organic substance biosynthetic process regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process tumor necrosis factor superfamily cytokine production regulation of cellular metabolic process positive regulation of tumor necrosis factor production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of cellular biosynthetic process regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process secretion by cell exocytosis secretion export from cell vesicle organization organelle organization endosome organization	symmetric synapse neuron to neuron synapse synapse cell junction cellular anatomical entity membrane polymeric cytoskeletal fiber membrane-bounded organelle intracellular anatomical structure axoneme axonemal microtubule cytoplasmic microtubule plasma membrane bounded cell projection cytoplasm intracellular organelle symmetric synapse neuron to neuron synapse synapse cell junction cellular anatomical entity membrane polymeric cytoskeletal fiber membrane-bounded organelle intracellular anatomical structure axoneme axonemal microtubule cytoplasmic microtubule plasma membrane bounded cell projection cytoplasm intracellular organelle cytoskeleton supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle ciliary plasm cilium cytoplasmic region plasma membrane bounded cell projection cell projection organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular fiber microtubule centrosome microtubule organizing center cytosol intracellular membrane-bounded organelle presynapse GABA-ergic synapse glutamatergic synapse cytoplasmic vesicle intracellular vesicle vesicle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment endomembrane system trans-Golgi network Golgi membrane bounding membrane of organelle organelle membrane endosome recycling endosome neuron spine neuron projection dendritic spine somatodendritic compartment postsynapse dendrite dendritic tree perinuclear region of cytoplasm asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR046455	Sec7/BIG1-like, C-terminal domain	Domain
A	IPR032691	Mon2/Sec7/BIG1-like, HUS domain	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR035999	Sec7 domain superfamily	Homologous Superfamily
A	IPR000904	Sec7 domain	Domain
A	IPR023394	Sec7, C-terminal domain superfamily	Homologous Superfamily
A	IPR032629	Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain	Domain
A	IPR015403	Mon2/Sec7/BIG1-like, HDS	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y6D5	periventricular nodular heterotopia periventricular heterotopia with microcephaly, autosomal recessive adenoma colorectal cancer glioblastoma large cell medulloblastoma microcephaly astrocytic tumor endogenous depression IgA glomerulonephritis Malformations of Cortical Development osteosarcoma colorectal adenoma intellectual disability ovarian cancer periventricular nodular heterotopia periventricular heterotopia with microcephaly, autosomal recessive adenoma colorectal cancer glioblastoma large cell medulloblastoma microcephaly astrocytic tumor endogenous depression IgA glomerulonephritis Malformations of Cortical Development osteosarcoma colorectal adenoma intellectual disability ovarian cancer plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.