3SN2

Crystal structure analysis of iron regulatory protein 1 in complex with transferrin receptor IRE B RNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3sn2a2	Alpha and beta proteins (a/b)	The 'swivelling' beta/beta/alpha domain	LeuD/IlvD-like	automated matches	automated matches	rabbit (Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)
A	d3sn2a1	Alpha and beta proteins (a/b)	Aconitase iron-sulfur domain	Aconitase iron-sulfur domain	Aconitase iron-sulfur domain	automated matches	rabbit (Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aconitase_C	e3sn2A2	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Aconitase_C	ECOD (1.6)
A	Aconitase	e3sn2A3	A: a/b three-layered sandwiches	X: Aconitase iron-sulfur domain (From Homology)	H: Aconitase iron-sulfur domain	T: Aconitase iron-sulfur domain	F: Aconitase	ECOD (1.6)
A	Aconitase	e3sn2A5	A: a/b three-layered sandwiches	X: Aconitase iron-sulfur domain (From Homology)	H: Aconitase iron-sulfur domain	T: Aconitase iron-sulfur domain II	F: Aconitase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.499.10	Alpha Beta	2-Layer Sandwich	Aconitase	domain 3	CATH (4.3.0)
A	3.20.19.10	Alpha Beta	Alpha-Beta Barrel	Aconitase	domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00330	Aconitase family (aconitate hydratase) (Aconitase)	Aconitase family (aconitate hydratase)	-	Family
A	PF00694	Aconitase C-terminal domain (Aconitase_C)	Aconitase C-terminal domain	Members of this family usually also match to Pfam:PF00330. This domain undergoes conformational change in the enzyme mechanism [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cytoplasmic aconitate hydratase	aconitate hydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity RNA binding iron-responsive element binding binding organic cyclic compound binding nucleic acid binding mRNA binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding aconitate hydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity RNA binding iron-responsive element binding binding organic cyclic compound binding nucleic acid binding mRNA binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process primary metabolic process generation of precursor metabolites and energy organic substance metabolic process tricarboxylic acid metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process primary metabolic process generation of precursor metabolites and energy organic substance metabolic process tricarboxylic acid metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process organic acid metabolic process citrate metabolic process response to iron(II) ion response to stimulus response to metal ion response to iron ion response to chemical response to inorganic substance	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
B	transferrin receptor iron regulatory element B RNA	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000573	Aconitase A/isopropylmalate dehydratase small subunit, swivel domain	Domain
A	IPR036008	Aconitase, iron-sulfur domain	Homologous Superfamily
A	IPR006249	Aconitase/Iron-responsive element-binding protein 2	Family
A	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain	Domain
A	IPR015928	Aconitase/3-isopropylmalate dehydratase, swivel	Homologous Superfamily
A	IPR015931	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3	Homologous Superfamily
A	IPR044137	Aconitase A, swivel domain	Domain
A	IPR018136	Aconitase family, 4Fe-4S cluster binding site	Binding Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.