3SJA

Crystal structure of S. cerevisiae Get3 in the open state in complex with Get1 cytosolic domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Simibi-like P-loop NTPases	8017940	3002018	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Simibi-like P-loop NTPases	8017940	3002018	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Simibi-like P-loop NTPases	8017940	3002018	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Simibi-like P-loop NTPases	8017940	3002018	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Simibi-like P-loop NTPases	8017940	3002018	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Get1 cytosolic domain-like	8092327	3002588	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Get1 cytosolic domain-like	8092327	3002588	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Get1 cytosolic domain-like	8092327	3002588	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Get1 cytosolic domain-like	8092327	3002588	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Get1 cytosolic domain-like	8092327	3002588	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02374	e3sjaA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02374	ECOD (1.6)
B	PF02374	e3sjaB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02374	ECOD (1.6)
E	PF02374	e3sjaE1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02374	ECOD (1.6)
F	PF02374	e3sjaF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02374	ECOD (1.6)
I	PF02374	e3sjaI1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02374	ECOD (1.6)
C	PF04420	e3sjaC1	A: alpha bundles	X: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	H: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	T: Golgi to ER traffic protein 1 cytosolic domain	F: PF04420	ECOD (1.6)
D	PF04420	e3sjaD1	A: alpha bundles	X: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	H: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	T: Golgi to ER traffic protein 1 cytosolic domain	F: PF04420	ECOD (1.6)
G	PF04420	e3sjaG1	A: alpha bundles	X: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	H: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	T: Golgi to ER traffic protein 1 cytosolic domain	F: PF04420	ECOD (1.6)
H	PF04420	e3sjaH1	A: alpha bundles	X: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	H: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	T: Golgi to ER traffic protein 1 cytosolic domain	F: PF04420	ECOD (1.6)
J	PF04420	e3sjaJ1	A: alpha bundles	X: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	H: Golgi to ER traffic protein 1 cytosolic domain (From Topology)	T: Golgi to ER traffic protein 1 cytosolic domain	F: PF04420	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
E	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
F	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
I	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	1.10.287.660	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
D	1.10.287.660	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
G	1.10.287.660	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
H	1.10.287.660	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
J	1.10.287.660	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E, F, I	PF02374	Anion-transporting ATPase (ArsA_ATPase)	Anion-transporting ATPase	This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell.	Domain
C, D, G, H, J	PF04420	CHD5-like protein (CHD5)	CHD5-like protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E, F, I	ATPase GET3	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding protein binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity protein folding chaperone cation binding metal ion binding identical protein binding	localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane protein localization to membrane localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane protein localization to membrane endoplasmic reticulum organization cellular component organization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization tail-anchored membrane protein insertion into ER membrane cellular response to stimulus response to organic substance regulation of cellular process sexual reproduction response to stimulus signaling regulation of reproductive process reproductive process positive regulation of biological process regulation of conjugation with cellular fusion response to pheromone cellular response to pheromone cell communication positive regulation of conjugation with cellular fusion cellular response to organic substance signal transduction positive regulation of reproductive process pheromone-dependent signal transduction involved in conjugation with cellular fusion regulation of biological process signal transduction involved in positive regulation of conjugation with cellular fusion biological regulation conjugation with cellular fusion response to pheromone triggering conjugation with cellular fusion cellular response to chemical stimulus response to chemical protein targeting post-translational protein targeting to endoplasmic reticulum membrane protein targeting to membrane establishment of protein localization to organelle establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER response to metal ion response to inorganic substance response to stress response to heat response to abiotic stimulus response to temperature stimulus response to arsenic-containing substance	membrane-bounded organelle protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular membrane-bounded organelle endomembrane system GET complex intracellular organelle organelle endoplasmic reticulum cytoplasm endoplasmic reticulum protein-containing complex Golgi apparatus cytosol membrane-bounded organelle protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular membrane-bounded organelle endomembrane system GET complex intracellular organelle organelle endoplasmic reticulum cytoplasm endoplasmic reticulum protein-containing complex Golgi apparatus cytosol organelle subcompartment membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane
C, D, G, H, J	Golgi to ER traffic protein 1	protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane protein localization to membrane localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane protein localization to membrane endoplasmic reticulum organization cellular component organization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization tail-anchored membrane protein insertion into ER membrane cellular component disassembly catabolic process macroautophagy cellular metabolic process autophagy cellular catabolic process mitophagy organelle disassembly metabolic process autophagy of mitochondrion process utilizing autophagic mechanism mitochondrion organization	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex endomembrane system GET complex endoplasmic reticulum endoplasmic reticulum protein-containing complex Golgi membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex endomembrane system GET complex endoplasmic reticulum endoplasmic reticulum protein-containing complex Golgi membrane Golgi apparatus membrane bounding membrane of organelle organelle membrane mitochondrial membrane organelle envelope mitochondrial envelope organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E, F, I	IPR027542	Arsenical pump ATPase, ArsA/GET3, eukaryotic	Family
A, B, E, F, I	IPR016300	Arsenical pump ATPase, ArsA/GET3	Family
A, B, E, F, I	IPR025723	Anion-transporting ATPase-like domain	Domain
A, B, E, F, I	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C, D, G, H, J	IPR027538	Get 1, fungi	Family
C, D, G, H, J	IPR029012	Helix hairpin bin domain superfamily	Homologous Superfamily
C, D, G, H, J	IPR028945	Get1 family	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
C, D, G, H, J	OPM	Monotopic/peripheral	Alpha/Beta monotopic/peripheral	P-loop containing nucleoside triphosphate hydrolases	ArsA ATPase

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.