Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ASGL_5e3s8vA6 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 6-bladedF: SGL_5ECOD (1.6)
AFXa_inhibitione3s8vA5 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: FXa_inhibitionECOD (1.6)
BSGL_5e3s8vB2 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 6-bladedF: SGL_5ECOD (1.6)
BFXa_inhibitione3s8vB1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: FXa_inhibitionECOD (1.6)
C [auth X]KOG1218_likee3s8vX1 A: few secondary structure elementsX: omega toxin-likeH: omega toxin-relatedT: Colipase-likeF: KOG1218_likeECOD (1.6)
C [auth X]Prokineticin_likee3s8vX2 A: few secondary structure elementsX: omega toxin-likeH: omega toxin-relatedT: Colipase-likeF: Prokineticin_likeECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.120.10.30 Mainly Beta 6 Propeller Neuraminidase TolB, C-terminal domainCATH (4.3.0)
B2.120.10.30 Mainly Beta 6 Propeller Neuraminidase TolB, C-terminal domainCATH (4.3.0)
C [auth X]2.10.80.10 Mainly Beta Ribbon Lipase, subunit A Lipase, subunit ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF14670Coagulation Factor Xa inhibitory site (FXa_inhibition)Coagulation Factor Xa inhibitory siteThis short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442 [1].Domain
A, B
PF00058Low-density lipoprotein receptor repeat class B (Ldl_recept_b)Low-density lipoprotein receptor repeat class B- Repeat
C [auth X]PF21481Dickkopf-related protein 1/2/4, C-terminal subdomain 1 (DIKK1-2-4_C-subdom1)Dickkopf-related protein 1/2/4, C-terminal subdomain 1Dickkopf-related proteins are cysteine-rich secretory proteins and highly conserved inhibitors of the canonical Wnt signaling pathway, which play key roles in many essential biological processes. This entry represents the C-terminal cysteine-rich dom ...Dickkopf-related proteins are cysteine-rich secretory proteins and highly conserved inhibitors of the canonical Wnt signaling pathway, which play key roles in many essential biological processes. This entry represents the C-terminal cysteine-rich domain which is strongly conserved in Dkk1, Dkk2 and Dkk4, and directly contacts LRP6 [1-4]. This domain is described as two subdomains, each consisting of three anti-parallel beta-strands that are connected by a long loop which contains a short alpha-helix. This entry represents the first subdomain, the second is covered in Pfam:PF21479. In Dkk3 the residues differ and is consistent with studies indicating that Dkk3 is a divergent family member that does not inhibit Wnt signalling [4]. This domain share significant sequence similarity to the colipase fold.
Domain
C [auth X]PF21479Dickkopf-related protein 1/2/4, C-terminal subdomain 2 (DIKK1-2-4_C-subdom2)Dickkopf-related protein 1/2/4, C-terminal subdomain 2Dickkopf-related proteins are cysteine-rich secretory proteins and highly conserved inhibitors of the canonical Wnt signaling pathway, which play key roles in many essential biological processes. The C-terminal domain is described as two subdomains, ...Dickkopf-related proteins are cysteine-rich secretory proteins and highly conserved inhibitors of the canonical Wnt signaling pathway, which play key roles in many essential biological processes. The C-terminal domain is described as two subdomains, each consisting of three anti-parallel beta-strands that are connected by a long loop which contains a short alpha-helix. This domain is strongly conserved in Dkk1, Dkk2 and Dkk4, and directly contacts LRP6. This entry represents the second subdomain [1-4]. In Dkk3 these residues differ and is consistent with studies indicating that Dkk3 is a divergent family member that does not inhibit Wnt signalling [4]. This domain share significant sequence similarity to the colipase fold.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Low-density lipoprotein receptor-related protein 6
C [auth X]Dickkopf-related protein 1

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B
PharosO75581
C [auth X]PharosO94907