3RPN

Crystal structure of human kappa class glutathione transferase in complex with S-hexylglutathione

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3rpna_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	DsbA-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3rpnb_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	DsbA-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3rpnc_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	DsbA-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3rpnd_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	DsbA-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d3rpne_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	DsbA-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d3rpnf_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	DsbA-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DsbA-like	8079084	4000595	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioredoxin-like	8079085	3000031	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Thioredoxin-like	8079085	3000031	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thioredoxin-like	8079085	3000031	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thioredoxin-like	8079085	3000031	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Thioredoxin-like	8079085	3000031	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Thioredoxin-like	8079085	3000031	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01323	e3rpnA1	A: alpha arrays	X: Insertion subdomain in DsbA-like	H: Insertion subdomain in DsbA-like (From Topology)	T: Insertion subdomain in DsbA-like	F: PF01323	ECOD (1.6)
A	PF01323	e3rpnA2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF01323	ECOD (1.6)
B	PF01323	e3rpnB1	A: alpha arrays	X: Insertion subdomain in DsbA-like	H: Insertion subdomain in DsbA-like (From Topology)	T: Insertion subdomain in DsbA-like	F: PF01323	ECOD (1.6)
B	PF01323	e3rpnB2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF01323	ECOD (1.6)
C	PF01323	e3rpnC1	A: alpha arrays	X: Insertion subdomain in DsbA-like	H: Insertion subdomain in DsbA-like (From Topology)	T: Insertion subdomain in DsbA-like	F: PF01323	ECOD (1.6)
C	PF01323	e3rpnC2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF01323	ECOD (1.6)
D	PF01323	e3rpnD1	A: alpha arrays	X: Insertion subdomain in DsbA-like	H: Insertion subdomain in DsbA-like (From Topology)	T: Insertion subdomain in DsbA-like	F: PF01323	ECOD (1.6)
D	PF01323	e3rpnD2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF01323	ECOD (1.6)
E	PF01323	e3rpnE1	A: alpha arrays	X: Insertion subdomain in DsbA-like	H: Insertion subdomain in DsbA-like (From Topology)	T: Insertion subdomain in DsbA-like	F: PF01323	ECOD (1.6)
E	PF01323	e3rpnE2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF01323	ECOD (1.6)
F	PF01323	e3rpnF1	A: alpha arrays	X: Insertion subdomain in DsbA-like	H: Insertion subdomain in DsbA-like (From Topology)	T: Insertion subdomain in DsbA-like	F: PF01323	ECOD (1.6)
F	PF01323	e3rpnF2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF01323	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
B	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
C	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
D	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
E	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
F	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01323	DSBA-like thioredoxin domain (DSBA)	DSBA-like thioredoxin domain	This family contains a diverse set of proteins with a thioredoxin-like structure Pfam:PF00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyse one step in prokaryotic polyaromatic hydrocarbon (PAH) cataboli ...	This family contains a diverse set of proteins with a thioredoxin-like structure Pfam:PF00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyse one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways [2,3,4]. This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs (e.g. Swiss:P24473), whose similarity to HCCA isomerases was not previously recognised. The sequence Swiss:O07298 has been annotated as a dioxygenase but is almost certainly an HCCA isomerase enzyme. Similarly, the sequence Swiss:Q9ZI67 has been annotated as a dehydrogenase, but is most probably also an HCCA isomerase enzyme. In addition, the Rhizobium leguminosarum Swiss:Q52782 protein has been annotated as a putative glycerol-3-phosphate transfer protein, but is also most likely to be an HCCA isomerase enzyme (see [5]).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Glutathione S-transferase kappa 1	peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor glutathione peroxidase activity catalytic activity glutathione transferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups	developmental process epithelium development cellular developmental process cell differentiation anatomical structure development cellular process tissue development epithelial cell differentiation glutathione metabolic process organonitrogen compound metabolic process organic substance metabolic process cellular metabolic process metabolic process sulfur compound metabolic process developmental process epithelium development cellular developmental process cell differentiation anatomical structure development cellular process tissue development epithelial cell differentiation glutathione metabolic process organonitrogen compound metabolic process organic substance metabolic process cellular metabolic process metabolic process sulfur compound metabolic process amide metabolic process cellular modified amino acid metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle peroxisome microbody cytosol peroxisomal matrix membrane-enclosed lumen intracellular organelle lumen organelle lumen microbody lumen mitochondrial matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001853	DSBA-like thioredoxin domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR014440	HCCA isomerase/glutathione S-transferase kappa	Family
A, B, C, D, E A, B, C, D, E, F	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR044088	Glutathione S-transferase kappa	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9Y2Q3	prostate cancer glioblastoma osteoarthritis susceptibility 1 ovarian cancer Prostatic Neoplasms malignant mesothelioma plasma cell myeloma subependymal giant cell astrocytoma osteoarthritis osteosarcoma tuberculosis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.