Annotations: 3RL8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3rl8a_	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3rl8b_	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3rl8c_	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3rl8d_	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d3rl8e_	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e3rl8A1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
B	PF00595	e3rl8B1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
C	PF00595	e3rl8C1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
D	PF00595	e3rl8D1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
E	PF00595	e3rl8E1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
C	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
D	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
E	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain
A, B, C, D, E	PF10600	PDZ-associated domain of NMDA receptors (PDZ_assoc)	PDZ-associated domain of NMDA receptors	This domain is found in higher eukaryotes between the second and third PDZ domains, Pfam:PF00595, of glutamate receptor like proteins. Its exact function is not known.	Domain
F	PF05937	EB-1 Binding Domain (EB1_binding)	EB-1 Binding Domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Disks large homolog 1	structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cytoskeletal protein binding protein binding structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cytoskeletal protein binding protein binding binding cell adhesion molecule binding cadherin binding potassium channel regulator activity channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity L27 domain binding protein domain specific binding nucleobase-containing compound kinase activity nucleoside monophosphate kinase activity kinase activity transferase activity guanylate kinase activity phosphotransferase activity, phosphate group as acceptor transferase activity, transferring phosphorus-containing groups molecular adaptor activity phosphatase binding enzyme binding kinase binding transmembrane transporter binding	developmental process multicellular organismal process sensory organ development eye development animal organ development visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development lens development in camera-type eye system development positive regulation of protein localization to plasma membrane protein localization developmental process multicellular organismal process sensory organ development eye development animal organ development visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development lens development in camera-type eye system development positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization cellular process regulation of protein localization to plasma membrane heart process system process regulation of actin filament-based process cardiac muscle cell action potential involved in contraction regulation of ventricular cardiac muscle cell action potential regulation of heart contraction regulation of system process cardiac muscle contraction striated muscle contraction circulatory system process regulation of cardiac muscle cell action potential actin filament-based process regulation of multicellular organismal process regulation of biological quality blood circulation cardiac muscle cell contraction regulation of action potential ventricular cardiac muscle cell action potential regulation of cardiac muscle contraction action potential actin filament-based movement muscle contraction muscle system process regulation of muscle system process regulation of blood circulation regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction heart contraction cardiac muscle cell action potential regulation of membrane potential negative regulation of lymphocyte proliferation regulation of leukocyte activation negative regulation of biological process regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade protein-containing complex localization bicellular tight junction assembly tight junction organization apical junction assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly tight junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization regulation of potassium ion transport transport regulation of transport regulation of monoatomic ion transport establishment of localization metal ion transport positive regulation of potassium ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport potassium ion transport monoatomic cation transport regulation of metal ion transport organic substance metabolic process organonitrogen compound metabolic process metabolic process primary metabolic process protein metabolic process macromolecule metabolic process amyloid precursor protein metabolic process trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport export across plasma membrane potassium ion export across plasma membrane monoatomic cation transmembrane transport export from cell inorganic ion transmembrane transport regulation of potassium ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport regulation of potassium ion export across plasma membrane regulation of monoatomic cation transmembrane transport negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process organelle organization actin cytoskeleton organization actin filament organization supramolecular fiber organization cytoskeleton organization receptor clustering regulation of transmembrane transporter activity regulation of transporter activity regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transmembrane transporter activity regulation of cation channel activity regulation of molecular function smooth muscle contraction phasic smooth muscle contraction peristalsis endothelial cell proliferation epithelial cell proliferation membrane organization membrane raft organization protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization protein-containing complex assembly positive regulation of cell population proliferation sodium ion transmembrane transport regulation of sodium ion transport regulation of sodium ion transmembrane transport sodium ion transport positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization positive regulation of cellular component organization regulation of cellular component size regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of protein polymerization regulation of actin filament polymerization regulation of actin filament organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of actin polymerization or depolymerization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization positive regulation of actin filament polymerization regulation of anatomical structure size establishment of organelle localization centrosome localization organelle localization establishment of localization in cell microtubule organizing center localization establishment of centrosome localization establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity protein localization to postsynaptic specialization membrane protein localization to postsynaptic membrane protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse hard palate development secondary palate development roof of mouth development embryonic organ morphogenesis chordate embryonic development embryonic morphogenesis embryo development anatomical structure morphogenesis embryo development ending in birth or egg hatching skeletal system development animal organ morphogenesis embryonic skeletal system development skeletal system morphogenesis embryonic organ development embryonic skeletal system morphogenesis cortical actin cytoskeleton organization cortical cytoskeleton organization regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction reproductive system development reproductive process reproductive structure development developmental process involved in reproduction regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation mesonephric epithelium development kidney epithelium development nephron morphogenesis branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis tube morphogenesis branching involved in ureteric bud morphogenesis renal tubule development epithelial tube morphogenesis nephron development nephron epithelium development ureteric bud development epithelium development tube development mesonephros development morphogenesis of an epithelium tissue development tissue morphogenesis kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis morphogenesis of a branching epithelium regulation of protein localization to synapse regulation of multicellular organismal development regulation of developmental process regulation of myelination nervous system development regulation of nervous system development myelination axon ensheathment ensheathment of neurons microtubule cytoskeleton organization cytoplasmic microtubule organization cortical microtubule organization microtubule-based process negative regulation of p38MAPK cascade p38MAPK cascade regulation of p38MAPK cascade import into cell potassium ion import across plasma membrane import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane regulation of potassium ion import regulation of cell shape cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis astral microtubule organization cell cycle spindle organization cell cycle process regulation of cell cycle phase transition negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition regulation of cell cycle negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition immunological synapse formation cell-cell recognition cell recognition muscle tissue development smooth muscle tissue development	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region cell-cell junction anchoring junction intracellular anatomical structure cytoplasm cytosol neuromuscular junction intercalated disc cell-cell contact zone apical part of cell apical plasma membrane axon cell projection main axon neuron projection node of Ranvier plasma membrane bounded cell projection cell projection membrane membrane microdomain membrane raft membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane immunological synapse lateral plasma membrane lateral loop myelin sheath myelin sheath abaxonal region basement membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle sarcolemma basal part of cell basal plasma membrane basolateral plasma membrane glutamatergic synapse adherens junction Golgi apparatus perinuclear region of cytoplasm polymeric cytoskeletal fiber cytoskeleton intracellular non-membrane-bounded organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex plasma membrane protein complex membrane protein complex MPP7-DLG1-LIN7 complex apical junction complex bicellular tight junction tight junction cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane nucleus
F	11-mer peptide from Adenomatous polyposis coli protein	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding enzyme regulator activity molecular function regulator activity protein kinase regulator activity kinase regulator activity microtubule plus-end binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding gamma-catenin binding cytoskeletal protein binding microtubule binding protein binding binding tubulin binding enzyme regulator activity molecular function regulator activity protein kinase regulator activity kinase regulator activity microtubule plus-end binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding gamma-catenin binding kinase binding protein kinase binding beta-catenin binding protein-containing complex binding dynein complex binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process cellular developmental process cell differentiation cell fate specification cell fate commitment multicellular organism development multicellular organismal process anatomical structure development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process cellular developmental process cell differentiation cell fate specification cell fate commitment multicellular organism development multicellular organismal process anatomical structure development pattern specification process regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization cell projection organization positive regulation of biological process plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization pseudopodium assembly cellular component assembly positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process regulation of biological process plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly biological regulation regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly positive regulation of pseudopodium assembly regulation of pseudopodium assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly pseudopodium organization signaling negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death regulation of microtubule-based process regulation of microtubule-based movement microtubule-based movement microtubule-based process cell migration cell motility bicellular tight junction assembly tight junction organization apical junction assembly cell junction organization cell junction assembly tight junction assembly cell-cell junction assembly cell-cell junction organization nervous system development system development cell adhesion establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore regulation of cell cycle process establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation regulation of attachment of spindle microtubules to kinetochore cell cycle establishment of chromosome localization regulation of cell cycle chromosome segregation cell cycle process protein-containing complex organization protein-containing complex assembly mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cytokinesis cell division mitotic cell cycle regulation of cell cycle phase transition spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling mitotic sister chromatid separation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition regulation of mitotic cell cycle mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition catabolic process positive regulation of protein metabolic process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process regulation of catalytic activity negative regulation of catalytic activity regulation of cyclin-dependent protein kinase activity regulation of transferase activity negative regulation of cellular metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process regulation of cyclin-dependent protein serine/threonine kinase activity phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of protein serine/threonine kinase activity negative regulation of macromolecule metabolic process negative regulation of cyclin-dependent protein kinase activity negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process heart development mesenchyme morphogenesis endocardial cushion morphogenesis animal organ development heart morphogenesis mesenchyme development tissue development circulatory system development tissue morphogenesis anatomical structure morphogenesis endocardial cushion development animal organ morphogenesis heart valve development cellular response to nitrogen compound response to organic substance response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone cellular response to organic substance enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus response to organonitrogen compound response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical response to insulin cellular response to insulin stimulus negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition negative regulation of G1/S transition of mitotic cell cycle negative regulation of cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion protein localization protein localization to microtubule cytoskeleton regulation of localization regulation of protein localization regulation of protein localization to centrosome protein localization to microtubule organizing center regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to cytoskeleton protein localization to organelle positive regulation of protein localization positive regulation of protein localization to centrosome protein localization to centrosome regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization negative regulation of microtubule depolymerization microtubule cytoskeleton organization protein-containing complex disassembly regulation of protein-containing complex disassembly microtubule polymerization or depolymerization regulation of microtubule depolymerization negative regulation of protein-containing complex disassembly negative regulation of supramolecular fiber organization cellular component disassembly negative regulation of microtubule polymerization or depolymerization regulation of protein depolymerization negative regulation of cytoskeleton organization negative regulation of protein depolymerization microtubule depolymerization regulation of supramolecular fiber organization supramolecular fiber organization protein depolymerization cytoskeleton organization regulation of microtubule cytoskeleton organization regulation of developmental process regulation of cell differentiation	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane plasma membrane membrane protein complex extrinsic component of membrane cell-cell junction adherens junction anchoring junction cell junction membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system perinuclear region of cytoplasm polymeric cytoskeletal fiber cytoskeleton intracellular non-membrane-bounded organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle ruffle leading edge membrane ruffle membrane plasma membrane region cell projection membrane centrosome microtubule organizing center catalytic complex beta-catenin destruction complex intracellular protein-containing complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Wnt signalosome chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome apical junction complex bicellular tight junction tight junction lateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR015143	L27-1	Domain
A, B, C, D, E	IPR016313	Disks large 1-like	Family
A, B, C, D, E	IPR019590	Disks large homologue 1, N-terminal PEST domain	Domain
A, B, C, D, E	IPR008144	Guanylate kinase-like domain	Domain
A, B, C, D, E	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
A, B, C, D, E	IPR001478	PDZ domain	Domain
A, B, C, D, E	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR020590	Guanylate kinase, conserved site	Conserved Site
A, B, C, D, E	IPR019583	Disks large homolog 1-4, PDZ-associated domain	Domain
A, B, C, D, E	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C, D, E	IPR001452	SH3 domain	Domain
A, B, C, D, E	IPR004172	L27 domain	Domain
A, B, C, D, E	IPR036034	PDZ superfamily	Homologous Superfamily
A, B, C, D, E	IPR036892	L27 domain superfamily	Homologous Superfamily
F	IPR016024	Armadillo-type fold	Homologous Superfamily
F	IPR009240	Adenomatous polyposis coli protein, 15 residue repeat	Repeat
F	IPR009232	EB-1 binding	Domain
F	IPR000225	Armadillo	Repeat
F	IPR009223	Adenomatous polyposis coli protein repeat	Repeat
F	IPR026818	Adenomatous polyposis coli (APC) family	Family
F	IPR036149	APC, N-terminal coiled-coil domain superfamily	Homologous Superfamily
F	IPR009224	SAMP	Repeat
F	IPR011989	Armadillo-like helical	Homologous Superfamily
F	IPR041257	Adenomatous polyposis coli (APC) repeat	Repeat
F	IPR026831	Adenomatous polyposis coli protein	Homologous Superfamily
F	IPR009234	Adenomatous polyposis coli protein basic domain	Domain
F	IPR032038	Adenomatous polyposis coli, N-terminal dimerisation domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: Q12959	cleft palate schizophrenia pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia acne breast cancer Cleft palate with cleft lip Gaucher disease malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease spina bifida allergic rhinitis Brugada syndrome intellectual disability cleft palate schizophrenia pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia acne breast cancer Cleft palate with cleft lip Gaucher disease malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease spina bifida allergic rhinitis Brugada syndrome intellectual disability medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis subependymal giant cell astrocytoma astrocytic tumor Down syndrome large cell medulloblastoma non-small cell lung carcinoma ovarian cancer
F	Pharos: P25054	medulloblastoma classic familial adenomatous polyposis glioblastoma colorectal cancer desmoid tumor hepatocellular carcinoma intellectual disability Adenomatous Polyps malignant colon neoplasm mismatch repair cancer syndrome 1 non-small cell lung carcinoma gastric cancer adenoma papillary adenoma follicular thyroid adenoma medulloblastoma classic familial adenomatous polyposis glioblastoma colorectal cancer desmoid tumor hepatocellular carcinoma intellectual disability Adenomatous Polyps malignant colon neoplasm mismatch repair cancer syndrome 1 non-small cell lung carcinoma gastric cancer adenoma papillary adenoma follicular thyroid adenoma Cenani-Lenz syndactyly syndrome giant cell glioblastoma rectal neoplasm granular cell carcinoma adult medulloblastoma microcystic adenoma liver cancer Gardner syndrome Lynch syndrome cancer prostate cancer colorectal adenoma tubular adenocarcinoma medullomyoblastoma with myogenic differentiation intestinal cancer familial adenomatous polyposis 1 benign colon neoplasm macrocytic anemia childhood medulloblastoma hepatoblastoma adenocarcinoma melanotic medulloblastoma inflammatory bowel disease adult acute respiratory distress syndrome benign mesothelioma liver neoplasm malignant glioma psoriasis colorectal adenocarcinoma colorectal carcinoma stomach carcinoma in situ medulloblastoma with extensive nodularity cribriform carcinoma of breast digestive system cancer attenuated familial adenomatous polyposis large cell medulloblastoma ovarian cancer benign neoplasm of pancreas Pick disease lung adenocarcinoma gastric carcinoma colon carcinoma rectal cancer schizophrenia mammary neoplasms, animal hereditary diffuse gastric adenocarcinoma hyperlipidemia adrenal cortex carcinoma desmoplastic/nodular medulloblastoma digestive system disease intestinal polyp atypical teratoid rhabdoid tumor pancreatic neoplasm benign neoplasm of stomach pilocytic astrocytoma lung benign neoplasm primitive neuroectodermal tumor gastric neoplasm malignant ependymoma genetic intestinal polyposis colonic neoplasm rectal carcinoma glioma cribriform carcinoma mesothelioma diabetes mellitus intestinal neoplasm astrocytic tumor exocrine pancreatic carcinoma autism oligodendroglioma familial hyperlipidemia