3RG1

Crystal structure of the RP105/MD-1 complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3rg1A2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF13855	e3rg1A1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
B [auth E]	F_UNCLASSIFIED	e3rg1E2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth E]	PF13855,PF18831	e3rg1E1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855,PF18831	ECOD (1.6)
C [auth I]	PF13855,PF18831	e3rg1I1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855,PF18831	ECOD (1.6)
D [auth M]	F_UNCLASSIFIED	e3rg1M2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth M]	PF13855	e3rg1M1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
E [auth B]	F_UNCLASSIFIED	e3rg1B2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth B]	PF13855	e3rg1B1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
F	F_UNCLASSIFIED	e3rg1F2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF13855	e3rg1F1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
G [auth J]	F_UNCLASSIFIED	e3rg1J2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth J]	PF13855	e3rg1J1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
H [auth N]	F_UNCLASSIFIED	e3rg1N2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth N]	PF13855	e3rg1N1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
I [auth C]	PF02221	e3rg1C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
J [auth D]	PF02221	e3rg1D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
L [auth H]	PF02221	e3rg1H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
M [auth K]	PF02221	e3rg1K1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
N [auth L]	PF02221	e3rg1L1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
K [auth G]	PF02221	e3rg1G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
O	PF02221	e3rg1O1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)
P	PF02221	e3rg1P1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02221	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth E]	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
I [auth C]	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
J [auth D]	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
L [auth H]	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
M [auth K]	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
N [auth L]	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
K [auth G]	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
O	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
P	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth E], C [auth I], D [auth M], E [auth B], A, B [auth E], C [auth I], D [auth M], E [auth B], F, G [auth J], H [auth N]	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A, B [auth E], C [auth I], D [auth M], E [auth B], A, B [auth E], C [auth I], D [auth M], E [auth B], F, G [auth J], H [auth N]	PF18831	Leucine-rich repeat (LRR_11)	Leucine-rich repeat	-	Repeat
I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], N [auth L], O, P	PF02221	ML domain (E1_DerP2_DerF2)	ML domain	ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pa ...	ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 (Swiss:Q15668) causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth E], C [auth I], D [auth M], E [auth B], A, B [auth E], C [auth I], D [auth M], E [auth B], F, G [auth J], H [auth N]	CD180 molecule	-	-	membrane cellular anatomical entity
I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], N [auth L], O, P	LY86 protein	-	response to stimulus immune response immune system process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth E], C [auth I], D [auth M], E [auth B], A, B [auth E], C [auth I], D [auth M], E [auth B], F, G [auth J], H [auth N]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B [auth E], C [auth I], D [auth M], E [auth B], A, B [auth E], C [auth I], D [auth M], E [auth B], F, G [auth J], H [auth N]	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A, B [auth E], C [auth I], D [auth M], E [auth B], A, B [auth E], C [auth I], D [auth M], E [auth B], F, G [auth J], H [auth N]	IPR001611	Leucine-rich repeat	Repeat
A, B [auth E], C [auth I], D [auth M], E [auth B], A, B [auth E], C [auth I], D [auth M], E [auth B], F, G [auth J], H [auth N]	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B [auth E], C [auth I], D [auth M], E [auth B], A, B [auth E], C [auth I], D [auth M], E [auth B], F, G [auth J], H [auth N]	IPR041281	CD180, leucine-rich repeat	Repeat
I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], N [auth L], O, P	IPR039945	Lymphocyte antigen 86	Family
I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], N [auth L], O, P	IPR014756	Immunoglobulin E-set	Homologous Superfamily
I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], I [auth C], J [auth D], K [auth G], L [auth H], M [auth K], N [auth L], O, P	IPR003172	MD-2-related lipid-recognition domain	Domain