Annotations: 3RD7

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acyl_CoA_thio	e3rd7A1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: Acyl_CoA_thio	ECOD (1.6)
A	4HBT_3_N	e3rd7A2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: 4HBT_3_N	ECOD (1.6)
B	Acyl_CoA_thio	e3rd7B2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: Acyl_CoA_thio	ECOD (1.6)
B	4HBT_3_N	e3rd7B1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: 4HBT_3_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.160.210	Mainly Beta	Beta Barrel	Porin	Acyl-CoA thioesterase, double hotdog domain	CATH (4.3.0)
B	2.40.160.210	Mainly Beta	Beta Barrel	Porin	Acyl-CoA thioesterase, double hotdog domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02551	Acyl-CoA thioesterase (Acyl_CoA_thio)	Acyl-CoA thioesterase	This family represents the thioesterase II domain. Two copies of this domain are found in a number of acyl-CoA thioesterases.	Domain
A, B	PF13622	Acyl-CoA thioesterase N-terminal domain (4HBT_3)	Acyl-CoA thioesterase N-terminal domain	This family contains a wide variety of enzymes, principally acyl-CoA thioesterases. These enzymes are part of the Hotdog fold superfamily [1]. This entry is usually found as the N-terminal part of a pair of HotDog domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Acyl-CoA thioesterase	hydrolase activity, acting on ester bonds thiolester hydrolase activity hydrolase activity fatty acyl-CoA hydrolase activity catalytic activity acyl-CoA hydrolase activity	ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process cellular process purine ribonucleotide metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003703	Acyl-CoA thioesterase	Family
A, B	IPR025652	Acyl-CoA thioesterase II domain	Domain
A, B	IPR049449	Acyl-CoA thioesterase-like, N-terminal HotDog domain	Domain
A, B	IPR029069	HotDog domain superfamily	Homologous Superfamily
A, B	IPR042171	Acyl-CoA thioesterase, double hotdog domain	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.