Annotations: 3R7W

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Roadblock/LC7 domain-like	8093370	3001810	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8093368	3002022	SCOP2B (2022-06-29)
C	SCOP2 Family	GTR1/2 C-terminal domain-like	8093369	4007806	SCOP2 (2022-06-29)
C	SCOP2 Family	Gtr1/RagA G domain-like	8046298	4005007	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Roadblock/LC7 domain-like	8093370	3001810	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Ras-like P-loop GTPases	8093368	3002022	SCOP2 (2022-06-29)
B	SCOP2 Family	GTR1/2 C-terminal domain-like	8093366	4007806	SCOP2 (2022-06-29)
B	SCOP2 Family	Gtr1/RagA G domain-like	8046295	4005007	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Roadblock/LC7 domain-like	8093367	3001810	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Ras-like P-loop GTPases	8093365	3002022	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Roadblock/LC7 domain-like	8093367	3001810	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04670	e3r7wA2	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF04670	ECOD (1.6)
A	PF04670	e3r7wA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF04670	ECOD (1.6)
C	PF04670	e3r7wC2	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF04670	ECOD (1.6)
C	PF04670	e3r7wC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF04670	ECOD (1.6)
B	PF04670	e3r7wB2	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF04670	ECOD (1.6)
B	PF04670	e3r7wB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF04670	ECOD (1.6)
D	PF04670	e3r7wD1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF04670	ECOD (1.6)
D	PF04670	e3r7wD2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF04670	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	3.30.450.190	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	3.30.450.190	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.30.450.190	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)
D	3.30.450.190	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF04670	Gtr1/RagA G protein conserved region (Gtr1_RagA)	Gtr1/RagA G protein conserved region	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of ...	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B [1,2,3,4].	Domain
B, D	PF04670	Gtr1/RagA G protein conserved region (Gtr1_RagA)	Gtr1/RagA G protein conserved region	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of ...	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B [1,2,3,4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	GTP-binding protein GTR1	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding protein binding	localization transport phosphate ion transport establishment of localization inorganic anion transport cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction localization transport phosphate ion transport establishment of localization inorganic anion transport cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling protein localization to vacuolar membrane protein localization cellular localization protein localization to vacuole localization within membrane protein localization to membrane cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of TORC1 signaling regulation of TORC1 signaling TORC1 signaling cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress response to starvation cellular response to starvation subtelomeric heterochromatin formation cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process chromosome organization regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase I organic cyclic compound biosynthetic process negative regulation of cellular catabolic process negative regulation of catabolic process catabolic process autophagy regulation of catabolic process regulation of autophagy cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process process utilizing autophagic mechanism microautophagy transcription by RNA polymerase III intracellular transport vesicle-mediated transport endocytic recycling endosomal transport vesicle-mediated transport to the plasma membrane establishment of localization in cell	Ragulator complex vacuolar membrane membrane-bounded organelle protein-containing complex intracellular anatomical structure membrane membrane protein complex vacuole cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle bounding membrane of organelle organelle cytoplasm Ragulator complex vacuolar membrane membrane-bounded organelle protein-containing complex intracellular anatomical structure membrane membrane protein complex vacuole cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane guanyl-nucleotide exchange factor complex intracellular protein-containing complex endosome membrane endosome intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane late endosome vesicle catalytic complex GTPase complex Gtr1-Gtr2 GTPase complex storage vacuole lytic vacuole fungal-type vacuole lytic vacuole membrane fungal-type vacuole membrane intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle nucleus
B, D	GTP-binding protein GTR2	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress response to starvation cellular response to starvation negative regulation of cellular catabolic process negative regulation of catabolic process catabolic process cellular metabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of cellular metabolic process regulation of catabolic process regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process negative regulation of cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process microautophagy protein localization to vacuolar membrane protein localization cellular localization protein localization to vacuole localization within membrane protein localization to membrane localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process transport intracellular transport establishment of localization vesicle-mediated transport endocytic recycling endosomal transport vesicle-mediated transport to the plasma membrane establishment of localization in cell	protein-containing complex catalytic complex GTPase complex Gtr1-Gtr2 GTPase complex vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole protein-containing complex catalytic complex GTPase complex Gtr1-Gtr2 GTPase complex vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle cytoplasm organelle membrane fungal-type vacuole membrane Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex endosome intracellular vesicle endomembrane system cytoplasmic vesicle late endosome vesicle endosome membrane late endosome membrane cytoplasmic vesicle membrane vesicle membrane protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR039397	RagA/B	Family
A, C	IPR006762	Gtr1/RagA G protein	Family
A, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B, D	IPR039400	RagC/D	Family
B, D	IPR006762	Gtr1/RagA G protein	Family
B, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.