3R69

Molecular analysis of the interaction of the HDL-receptor SR-BI with the PDZ3 domain of its adaptor protein PDZK1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3r69a1	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	mouse,mouse (Mus musculus ) [TaxId: 10090 ], mouse,mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d3r69a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse,mouse (Mus musculus ) [TaxId: 10090 ], mouse,mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d3r69b1	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	mouse,mouse (Mus musculus ) [TaxId: 10090 ], mouse,mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d3r69b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse,mouse (Mus musculus ) [TaxId: 10090 ], mouse,mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e3r69A1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
B	PDZ	e3r69B1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Scavenger receptor class B member 1	protein binding binding signaling receptor binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding PDZ domain binding protein domain specific binding scavenger receptor binding	regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation establishment of localization localization regulation of monoatomic anion transport monoatomic anion transport monoatomic ion transport protein localization protein localization to cell periphery cellular localization regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation establishment of localization localization regulation of monoatomic anion transport monoatomic anion transport monoatomic ion transport protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization cellular process localization within membrane protein localization to membrane establishment of protein localization regulation of cellular process regulation of protein localization protein targeting positive regulation of biological process positive regulation of establishment of protein localization regulation of protein targeting to membrane regulation of protein localization to membrane positive regulation of cellular process establishment of protein localization to membrane regulation of establishment of protein localization positive regulation of protein localization to membrane protein targeting to membrane regulation of cellular localization regulation of protein targeting positive regulation of protein localization positive regulation of protein targeting to membrane developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development	cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane plasma membrane bounded cell projection cell projection actin-based cell projection microvillus microvillus membrane cell projection membrane brush border membrane cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane plasma membrane bounded cell projection cell projection actin-based cell projection microvillus microvillus membrane cell projection membrane brush border membrane cluster of actin-based cell projections brush border

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036034	PDZ superfamily	Homologous Superfamily
A, B	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.