Annotations: 3R0L

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d3r0ld_	All alpha proteins	Phospholipase A2, PLA2	Phospholipase A2, PLA2	Vertebrate phospholipase A2	automated matches	(Crotalus durissus terrificus ) [TaxId: 8732 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2 Family	Vertebrate phospholipase A2	8062762	4001493	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Phospholipase A2 PLA2	8062763	3001690	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PF00068	e3r0lD1	A: few secondary structure elements	X: Phospholipase A2, PLA2 (From Topology)	H: Phospholipase A2, PLA2 (From Topology)	T: Phospholipase A2, PLA2	F: PF00068	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	1.20.90.10	Mainly Alpha	Up-down Bundle	Phospholipase A2	Phospholipase A2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00068	Phospholipase A2 (Phospholip_A2_1)	Phospholipase A2	Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disul ...	Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognised. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognises both families.	Domain
B	PF00068	Phospholipase A2 (Phospholip_A2_1)	Phospholipase A2	Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disul ...	Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognised. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognises both families.	Domain
D	PF00068	Phospholipase A2 (Phospholip_A2_1)	Phospholipase A2	Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disul ...	Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognised. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognises both families.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Crotoxin chain A	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phospholipase A2 activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity toxin activity	lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process cellular metabolic process phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process cellular metabolic process phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process organic anion transport carboxylic acid transport secretion transport arachidonate transport organic substance transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport icosanoid transport macromolecule localization icosanoid secretion long-chain fatty acid transport arachidonic acid secretion	extracellular region cellular anatomical entity
B	Crotoxin chain B	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phospholipase A2 activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity toxin activity	lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process cellular metabolic process phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process cellular metabolic process phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process organic anion transport carboxylic acid transport secretion transport arachidonate transport organic substance transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport icosanoid transport macromolecule localization icosanoid secretion long-chain fatty acid transport arachidonic acid secretion	extracellular region cellular anatomical entity
C	Crotoxin chain C	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phospholipase A2 activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity toxin activity	lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process cellular metabolic process phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process cellular metabolic process phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process organic anion transport carboxylic acid transport secretion transport arachidonate transport organic substance transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport icosanoid transport macromolecule localization icosanoid secretion long-chain fatty acid transport arachidonic acid secretion	extracellular region cellular anatomical entity
D	Phospholipase A2 CB	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity phospholipase A2 activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity phospholipase A2 activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity toxin activity	lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process cellular metabolic process phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process lipid catabolic process organic substance metabolic process catabolic process primary metabolic process metabolic process organic substance catabolic process lipid metabolic process cellular metabolic process phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process organic anion transport carboxylic acid transport secretion transport arachidonate transport organic substance transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport icosanoid transport macromolecule localization icosanoid secretion long-chain fatty acid transport arachidonic acid secretion	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR033112	Phospholipase A2, aspartic acid active site	Active Site
A	IPR036444	Phospholipase A2 domain superfamily	Homologous Superfamily
A	IPR033113	Phospholipase A2, histidine active site	Active Site
A	IPR001211	Phospholipase A2	Family
A	IPR016090	Phospholipase A2 domain	Domain
B	IPR033112	Phospholipase A2, aspartic acid active site	Active Site
B	IPR036444	Phospholipase A2 domain superfamily	Homologous Superfamily
B	IPR033113	Phospholipase A2, histidine active site	Active Site
B	IPR001211	Phospholipase A2	Family
B	IPR016090	Phospholipase A2 domain	Domain
C	IPR033112	Phospholipase A2, aspartic acid active site	Active Site
C	IPR036444	Phospholipase A2 domain superfamily	Homologous Superfamily
C	IPR033113	Phospholipase A2, histidine active site	Active Site
C	IPR001211	Phospholipase A2	Family
C	IPR016090	Phospholipase A2 domain	Domain
D	IPR033112	Phospholipase A2, aspartic acid active site	Active Site
D	IPR033113	Phospholipase A2, histidine active site	Active Site
D	IPR001211	Phospholipase A2	Family
D	IPR036444	Phospholipase A2 domain superfamily	Homologous Superfamily
D	IPR016090	Phospholipase A2 domain	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	PCA	Parent Component: GLN RESID: AA0031 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420
C	PCA	Parent Component: GLN RESID: AA0031 , AA0031 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420 , 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420