Annotations: 3QYE

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RabGAP-TBC_N	e3qyeA3	A: alpha arrays	X: Ypt/Rab-GAP domain of gyp1p-like	H: Ypt/Rab-GAP domain of gyp1p (From Topology)	T: Ypt/Rab-GAP domain of gyp1p	F: RabGAP-TBC_N	ECOD (1.6)
A	RabGAP-TBC_C	e3qyeA4	A: alpha arrays	X: Ypt/Rab-GAP domain of gyp1p-like	H: Ypt/Rab-GAP domain of gyp1p (From Topology)	T: Ypt/Rab-GAP domain of gyp1p	F: RabGAP-TBC_C	ECOD (1.6)
B	RabGAP-TBC_N	e3qyeB1	A: alpha arrays	X: Ypt/Rab-GAP domain of gyp1p-like	H: Ypt/Rab-GAP domain of gyp1p (From Topology)	T: Ypt/Rab-GAP domain of gyp1p	F: RabGAP-TBC_N	ECOD (1.6)
B	RabGAP-TBC_C	e3qyeB2	A: alpha arrays	X: Ypt/Rab-GAP domain of gyp1p-like	H: Ypt/Rab-GAP domain of gyp1p (From Topology)	T: Ypt/Rab-GAP domain of gyp1p	F: RabGAP-TBC_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.2750	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
A	1.10.8.270	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
A	1.10.472.80	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)
B	1.10.10.2750	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
B	1.10.8.270	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
B	1.10.472.80	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00566	Rab-GTPase-TBC domain (RabGAP-TBC)	Rab-GTPase-TBC domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	TBC1 domain family member 1	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity	-	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR035969	Rab-GAP-TBC domain superfamily	Homologous Superfamily
A, B	IPR006020	PTB/PI domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR000195	Rab-GAP-TBC domain	Domain
A, B	IPR021785	Domain of unknown function DUF3350	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q86TI0	obesity disorder astrocytic tumor gastric carcinoma lung adenocarcinoma lymphoplasmacytic lymphoma medulloblastoma osteosarcoma tuberculosis Crohn disease glioblastoma lung cancer malignant ependymoma non-small cell lung carcinoma ovarian cancer diabetes mellitus obesity disorder astrocytic tumor gastric carcinoma lung adenocarcinoma lymphoplasmacytic lymphoma medulloblastoma osteosarcoma tuberculosis Crohn disease glioblastoma lung cancer malignant ependymoma non-small cell lung carcinoma ovarian cancer diabetes mellitus interstitial cystitis lung carcinoma malignant mesothelioma subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.