Annotations: 3QYB

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RabGAP-TBC_N	e3qybA3	A: alpha arrays	X: Ypt/Rab-GAP domain of gyp1p-like	H: Ypt/Rab-GAP domain of gyp1p (From Topology)	T: Ypt/Rab-GAP domain of gyp1p	F: RabGAP-TBC_N	ECOD (1.6)
A	RabGAP-TBC_C	e3qybA4	A: alpha arrays	X: Ypt/Rab-GAP domain of gyp1p-like	H: Ypt/Rab-GAP domain of gyp1p (From Topology)	T: Ypt/Rab-GAP domain of gyp1p	F: RabGAP-TBC_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.2750	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
A	1.10.8.270	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
A	1.10.472.80	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00566	Rab-GTPase-TBC domain (RabGAP-TBC)	Rab-GTPase-TBC domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TBC1 domain family member 4	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity	localization transport cellular process establishment of localization vesicle-mediated transport cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus localization transport cellular process establishment of localization vesicle-mediated transport cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to chemical response to insulin cellular response to organic substance cellular response to insulin stimulus cellular response to hormone stimulus regulation of localization regulation of cellular component organization regulation of cellular process membrane fusion organelle membrane fusion negative regulation of biological process regulation of vesicle fusion negative regulation of vesicle fusion negative regulation of transport vesicle organization cellular component organization negative regulation of cellular process cellular component organization or biogenesis membrane organization regulation of biological process negative regulation of cellular component organization regulation of transport biological regulation regulation of vesicle-mediated transport regulation of organelle organization organelle fusion organelle organization negative regulation of organelle organization vesicle fusion	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle organelle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035969	Rab-GAP-TBC domain superfamily	Homologous Superfamily
A	IPR006020	PTB/PI domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR000195	Rab-GAP-TBC domain	Domain
A	IPR021785	Domain of unknown function DUF3350	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O60343	diabetes mellitus, noninsulin-dependent, 5 acquired metabolic disease breast cancer diabetes mellitus inborn carbohydrate metabolic disorder osteosarcoma psoriasis adrenal cortex carcinoma breast carcinoma invasive ductal breast carcinoma ovarian cancer type 2 diabetes mellitus atypical teratoid rhabdoid tumor dermatomyositis DOID:0081062 diabetes mellitus, noninsulin-dependent, 5 acquired metabolic disease breast cancer diabetes mellitus inborn carbohydrate metabolic disorder osteosarcoma psoriasis adrenal cortex carcinoma breast carcinoma invasive ductal breast carcinoma ovarian cancer type 2 diabetes mellitus atypical teratoid rhabdoid tumor dermatomyositis DOID:0081062 malignant colon neoplasm polycystic ovary syndrome

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.