3QE1

Crystal Structure of PDZ domain of sorting nexin 27 (SNX27) fused to the C-terminal residues (ESESKV) of GIRK3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3qe1a1	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	rat (Rattus norvegicus ) [TaxId: 10116 ], rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d3qe1a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	rat (Rattus norvegicus ) [TaxId: 10116 ], rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PDZ domain-like	8062276	3000388	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e3qe1A1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17655	Inward rectifier potassium channel C-terminal domain (IRK_C)	Inward rectifier potassium channel C-terminal domain	This cytoplasmic C-terminal domain has an Ig fold.	Domain
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sorting nexin-27, G protein-activated inward rectifier potassium channel 3 chimera	protein binding binding PDZ domain binding protein domain specific binding monoatomic cation transmembrane transporter activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity ligand-gated channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity protein binding binding PDZ domain binding protein domain specific binding monoatomic cation transmembrane transporter activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity ligand-gated channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity inward rectifier potassium channel activity gated channel activity potassium ion transmembrane transporter activity potassium channel activity voltage-gated monoatomic cation channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity voltage-gated potassium channel activity channel activity monoatomic ion transmembrane transporter activity G-protein activated inward rectifier potassium channel activity metal ion transmembrane transporter activity transmembrane transporter activity phospholipid binding lipid binding phosphatidylinositol binding ionotropic glutamate receptor binding signaling receptor binding glutamate receptor binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding	biological regulation regulation of biological quality regulation of presynaptic membrane potential regulation of membrane potential regulation of localization regulation of biological process regulation of cellular process transport regulation of transport monoatomic ion transmembrane transport regulation of monoatomic ion transport regulation of monoatomic ion transmembrane transport establishment of localization transmembrane transport biological regulation regulation of biological quality regulation of presynaptic membrane potential regulation of membrane potential regulation of localization regulation of biological process regulation of cellular process transport regulation of transport monoatomic ion transmembrane transport regulation of monoatomic ion transport regulation of monoatomic ion transmembrane transport establishment of localization transmembrane transport localization regulation of transmembrane transport monoatomic ion transport cellular process import into cell import across plasma membrane potassium ion transmembrane transport inorganic ion transmembrane transport inorganic cation import across plasma membrane metal ion transport inorganic cation transmembrane transport monoatomic cation transmembrane transport inorganic ion import across plasma membrane potassium ion transport potassium ion import across plasma membrane monoatomic cation transport protein localization positive regulation of AMPA glutamate receptor clustering regulation of postsynaptic membrane organization cellular localization positive regulation of cellular component organization regulation of cellular component organization regulation of protein localization regulation of AMPA glutamate receptor clustering positive regulation of postsynaptic membrane organization positive regulation of biological process cellular component organization receptor clustering cellular macromolecule localization cellular component organization or biogenesis synapse organization regulation of receptor clustering postsynaptic membrane organization regulation of protein localization to membrane positive regulation of cellular process membrane organization postsynapse organization positive regulation of receptor clustering AMPA glutamate receptor clustering positive regulation of protein localization to membrane glutamate receptor clustering neurotransmitter-gated ion channel clustering localization within membrane protein localization to membrane regulation of glutamate receptor clustering cell junction organization regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of postsynaptic membrane neurotransmitter receptor levels cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor cellular response to stimulus signaling signal transduction cell communication establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport establishment of localization in cell intracellular protein transport vesicle-mediated transport endosomal transport developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development response to amine response to organic substance response to methamphetamine hydrochloride response to organonitrogen compound response to chemical response to nitrogen compound protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane establishment of protein localization to plasma membrane endocytic recycling vesicle-mediated transport to the plasma membrane endosome to plasma membrane protein transport	parallel fiber to Purkinje cell synapse synapse cell junction cellular anatomical entity excitatory synapse cell periphery plasma membrane membrane presynapse presynaptic membrane plasma membrane region synaptic membrane protein-containing complex transmembrane transporter complex parallel fiber to Purkinje cell synapse synapse cell junction cellular anatomical entity excitatory synapse cell periphery plasma membrane membrane presynapse presynaptic membrane plasma membrane region synaptic membrane protein-containing complex transmembrane transporter complex membrane protein complex transporter complex monoatomic ion channel complex retromer complex endomembrane system intracellular anatomical structure WASH complex cytoplasm cytosol glutamatergic synapse membrane-bounded organelle early endosome endosome intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle vesicle immunological synapse endosome membrane early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041647	Inward rectifier potassium channel, C-terminal	Domain
A	IPR003276	Potassium channel, inwardly rectifying, Kir3.3	Family
A	IPR040445	Potassium channel, inwardly rectifying, transmembrane domain	Domain
A	IPR016449	Potassium channel, inwardly rectifying, Kir	Family
A	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic	Homologous Superfamily
A	IPR037835	SNX27, RA domain	Domain
A	IPR001683	Phox homology	Domain
A	IPR000159	Ras-associating domain	Domain
A	IPR037831	SNX17/27/31-like	Family
A	IPR037827	SNX27, atypical FERM-like domain	Domain
A	IPR037833	SNX27, PX domain	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR036871	PX domain superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.