Annotations: 3PZD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MyTH4 domain-like	8091827	3002546	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PH domain-like	8091831	3000134	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ubiquitin-like	8091829	3000157	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02174	e3pzdA5	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF02174	ECOD (1.6)
A	PF00373	e3pzdA3	A: alpha bundles	X: Acyl-CoA binding protein-like (From Topology)	H: Acyl-CoA binding protein-like (From Topology)	T: Acyl-CoA binding protein-like	F: PF00373	ECOD (1.6)
A	PF00784	e3pzdA4	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00784	ECOD (1.6)
A	PF21989	e3pzdA6	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF21989	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.530	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	MyTH4 domain	CATH (4.3.0)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)
A	1.20.80.10	Mainly Alpha	Up-down Bundle	Acyl-CoA Binding Protein		CATH (4.3.0)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00788	Ras association (RalGDS/AF-6) domain (RA)	Ras association (RalGDS/AF-6) domain	RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure [3] similar to that determined [1], and that of th ...	RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure [3] similar to that determined [1], and that of the RasGTP-binding domain of Raf kinase.	Domain
A	PF00373	FERM central domain (FERM_M)	FERM central domain	This domain is the central structural domain of the FERM domain.	Domain
A	PF00784	MyTH4 domain (MyTH4)	MyTH4 domain	-	Family
B	PF06583	Neogenin C-terminus (Neogenin_C)	Neogenin C-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Myosin-X	cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding actin binding actin filament binding cytoskeletal motor activity microfilament motor activity plus-end directed microfilament motor activity ATP-dependent activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding actin binding actin filament binding cytoskeletal motor activity microfilament motor activity plus-end directed microfilament motor activity ATP-dependent activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding phosphatidylinositol-3,4,5-trisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding calmodulin binding	regulation of biological process regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion regulation of cell-cell adhesion cellular process positive regulation of cellular process cellular response to stimulus response to stimulus regulation of biological process regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion regulation of cell-cell adhesion cellular process positive regulation of cellular process cellular response to stimulus response to stimulus signaling signal transduction cell communication developmental process regulation of developmental process regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis localization cellular localization transport establishment of localization in cell cytoskeleton-dependent intracellular transport intracellular transport establishment of localization filopodium assembly regulation of cellular component organization plasma membrane bounded cell projection organization cell projection organization regulation of cell projection organization regulation of cell projection assembly regulation of filopodium assembly plasma membrane bounded cell projection assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of plasma membrane bounded cell projection assembly cellular component assembly cellular component organization or biogenesis cell projection assembly regulation of plasma membrane bounded cell projection organization	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cell periphery cell cortex cytoplasm cytosol filopodium tip actin-based cell projection filopodium plasma membrane membrane protein-containing complex cytoskeleton actin cytoskeleton myosin complex neuron projection ruffle somatodendritic compartment cell body neuronal cell body filopodium membrane plasma membrane region cell projection membrane
B	Netrin receptor DCC	transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity netrin receptor activity identical protein binding protein binding binding	multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis dorsal/ventral axon guidance neuron projection guidance neuron development cellular process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of MAPK cascade biological regulation positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling anterior/posterior axon guidance apoptotic process cell death programmed cell death regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization positive regulation of neuron projection development positive regulation of cell projection organization regulation of cell projection organization regulation of plasma membrane bounded cell projection organization trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling postsynaptic modulation of chemical synaptic transmission central nervous system neuron development central nervous system neuron differentiation spinal cord development spinal cord ventral commissure morphogenesis central nervous system projection neuron axonogenesis central nervous system neuron axonogenesis central nervous system development neuron migration cell migration cell motility cell adhesion cell-cell adhesion	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region growth cone axon cell projection distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth cell surface growth cone membrane Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR000299	FERM domain	Domain
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR036124	Class X myosin, motor domain	Domain
A	IPR014352	FERM/acyl-CoA-binding protein superfamily	Homologous Superfamily
A	IPR019748	FERM central domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR000048	IQ motif, EF-hand binding site	Binding Site
A	IPR038185	MyTH4 domain superfamily	Homologous Superfamily
A	IPR031971	Unconventional myosin-X, coiled coil domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR019749	Band 4.1 domain	Domain
A	IPR000159	Ras-associating domain	Domain
A	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A	IPR041797	Myosin X, FERM domain C-lobe	Domain
A	IPR000857	MyTH4 domain	Domain
A	IPR001609	Myosin head, motor domain	Domain
A	IPR040640	Myosin X, N-terminal SH3 domain	Domain
B	IPR010560	Neogenin, C-terminal	Domain
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR003599	Immunoglobulin subtype	Domain
B	IPR003598	Immunoglobulin subtype 2	Domain
B	IPR013098	Immunoglobulin I-set	Domain
B	IPR003961	Fibronectin type III	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9HD67	Weight Gain atopic eczema ductal breast carcinoma in situ malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer cystic fibrosis lung cancer medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis Down syndrome malignant colon neoplasm Weight Gain atopic eczema ductal breast carcinoma in situ malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer cystic fibrosis lung cancer medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis Down syndrome malignant colon neoplasm myopathy ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis