Annotations: 3PXI

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth b]	SCOP2B Superfamily	Adapter protein MecA C-terminal domain-like	8092883	3002637	SCOP2B (2022-06-29)
A [auth a]	SCOP2B Superfamily	Adapter protein MecA C-terminal domain-like	8092883	3002637	SCOP2B (2022-06-29)
E [auth c]	SCOP2B Superfamily	Adapter protein MecA C-terminal domain-like	8092883	3002637	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	Double Clp-N motif	8082865	3001383	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Double Clp-N motif	8082865	3001383	SCOP2B (2022-06-29)
F [auth C]	SCOP2B Superfamily	Double Clp-N motif	8082865	3001383	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth b]	PF05389	e3pxib1	A: a+b two layers	X: Alpha-beta plaits	H: Adapter protein mecA 2 C-terminal domain (From Topology)	T: Adapter protein mecA 2 C-terminal domain	F: PF05389	ECOD (1.6)
A [auth a]	PF05389	e3pxia1	A: a+b two layers	X: Alpha-beta plaits	H: Adapter protein mecA 2 C-terminal domain (From Topology)	T: Adapter protein mecA 2 C-terminal domain	F: PF05389	ECOD (1.6)
E [auth c]	PF05389	e3pxic1	A: a+b two layers	X: Alpha-beta plaits	H: Adapter protein mecA 2 C-terminal domain (From Topology)	T: Adapter protein mecA 2 C-terminal domain	F: PF05389	ECOD (1.6)
B [auth A]	PF02861	e3pxiA13	A: alpha arrays	X: Histone-like	H: Histone-related	T: double Clp-N	F: PF02861	ECOD (1.6)
B [auth A]	PF10431	e3pxiA5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
B [auth A]	PF17871	e3pxiA4	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
B [auth A]	PF00004	e3pxiA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
B [auth A]	PF07724	e3pxiA3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
D [auth B]	PF02861	e3pxiB3	A: alpha arrays	X: Histone-like	H: Histone-related	T: double Clp-N	F: PF02861	ECOD (1.6)
D [auth B]	PF10431	e3pxiB6	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
D [auth B]	PF17871	e3pxiB5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
D [auth B]	PF00004	e3pxiB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
D [auth B]	PF07724	e3pxiB4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)
F [auth C]	PF02861	e3pxiC3	A: alpha arrays	X: Histone-like	H: Histone-related	T: double Clp-N	F: PF02861	ECOD (1.6)
F [auth C]	PF10431	e3pxiC6	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF10431	ECOD (1.6)
F [auth C]	PF17871	e3pxiC5	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17871	ECOD (1.6)
F [auth C]	PF00004	e3pxiC2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
F [auth C]	PF07724	e3pxiC4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07724	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth a], C [auth b], E [auth c]	PF05389	Negative regulator of genetic competence (MecA) (MecA)	Negative regulator of genetic competence (MecA)	-	Family
B [auth A], D [auth B], F [auth C]	PF17871	AAA lid domain (AAA_lid_9)	AAA lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
B [auth A], D [auth B], F [auth C]	PF02861	Clp amino terminal domain, pathogenicity island component (Clp_N)	Clp amino terminal domain, pathogenicity island component	-	Family
B [auth A], D [auth B], F [auth C]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
B [auth A], D [auth B], F [auth C]	PF07724	AAA domain (Cdc48 subfamily) (AAA_2)	AAA domain (Cdc48 subfamily)	This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth a], C [auth b], E [auth c]	Adapter protein mecA 1	protein-macromolecule adaptor activity molecular adaptor activity	DNA-mediated transformation cellular response to stimulus horizontal gene transfer response to stimulus establishment of competence for transformation cellular process regulation of biological process regulation of cellular process negative regulation of establishment of competence for transformation negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of response to stimulus regulation of establishment of competence for transformation DNA-mediated transformation cellular response to stimulus horizontal gene transfer response to stimulus establishment of competence for transformation cellular process regulation of biological process regulation of cellular process negative regulation of establishment of competence for transformation negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of response to stimulus regulation of establishment of competence for transformation negative regulation of cellular process sporulation resulting in formation of a cellular spore developmental process anatomical structure morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development sporulation regulation of developmental process negative regulation of sporulation resulting in formation of a cellular spore negative regulation of developmental process negative regulation of sporulation regulation of sporulation resulting in formation of a cellular spore regulation of sporulation	-
B [auth A], D [auth B], F [auth C]	Negative regulator of genetic competence ClpC/MecB	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	DNA-mediated transformation cellular response to stimulus horizontal gene transfer response to stimulus establishment of competence for transformation cellular process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth a], C [auth b], E [auth c]	IPR008681	Negative regulator of genetic competence, MecA	Family
A [auth a], C [auth b], E [auth c]	IPR038471	MecA, C-terminal domain superfamily	Homologous Superfamily
B [auth A], D [auth B], F [auth C]	IPR001270	ClpA/B family	Family
B [auth A], D [auth B], F [auth C]	IPR018368	ClpA/B, conserved site 1	Conserved Site
B [auth A], D [auth B], F [auth C]	IPR041546	ClpA/ClpB, AAA lid domain	Domain
B [auth A], D [auth B], F [auth C]	IPR004176	Clp, repeat (R) domain	Domain
B [auth A], D [auth B], F [auth C]	IPR028299	ClpA/B, conserved site 2	Conserved Site
B [auth A], D [auth B], F [auth C]	IPR003593	AAA+ ATPase domain	Domain
B [auth A], D [auth B], F [auth C]	IPR003959	ATPase, AAA-type, core	Domain
B [auth A], D [auth B], F [auth C]	IPR001943	UVR domain	Domain
B [auth A], D [auth B], F [auth C]	IPR019489	Clp ATPase, C-terminal	Domain
B [auth A], D [auth B], F [auth C]	IPR036628	Clp, N-terminal domain superfamily	Homologous Superfamily
B [auth A], D [auth B], F [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.