3PTY

Crystal structure of the C-terminal extracellular domain of Mycobacterium tuberculosis EmbC

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Arabino_trans_C_1st	e3ptyA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Arabino_trans_C_1st	ECOD (1.6)
A	Arabino_trans_C_2nd	e3ptyA2	A: a/b three-layered sandwiches	X: C-terminal domain in arabinosyltransferase C (From Topology)	H: C-terminal domain in arabinosyltransferase C (From Topology)	T: C-terminal domain in arabinosyltransferase C	F: Arabino_trans_C_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.190.160	Alpha Beta	3-Layer(aba) Sandwich	D-Maltodextrin-Binding Protein	domain 2	CATH (4.3.0)
A	2.60.120.940	Mainly Beta	Sandwich	Jelly Rolls	EmbC, C-terminal domain, subdomain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14896	EmbC C-terminal domain (Arabino_trans_C)	EmbC C-terminal domain	Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applicatio ...	Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol [1]. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Arabinosyltransferase C	pentosyltransferase activity arabinosyltransferase activity glycosyltransferase activity transferase activity catalytic activity	carbohydrate derivative biosynthetic process membrane lipid metabolic process cellular biosynthetic process glycolipid metabolic process cellular metabolic process liposaccharide metabolic process carbohydrate derivative metabolic process lipid biosynthetic process glycolipid biosynthetic process primary metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular lipid metabolic process carbohydrate derivative biosynthetic process membrane lipid metabolic process cellular biosynthetic process glycolipid metabolic process cellular metabolic process liposaccharide metabolic process carbohydrate derivative metabolic process lipid biosynthetic process glycolipid biosynthetic process primary metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular lipid metabolic process metabolic process cellular process membrane lipid biosynthetic process lipid metabolic process cellular component biogenesis peptidoglycan-based cell wall biogenesis cell wall biogenesis cell wall organization or biogenesis Actinobacterium-type cell wall biogenesis cellular component organization or biogenesis cellular component organization cell wall organization external encapsulating structure organization response to stimulus response to chemical response to antibiotic	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR040920	Arabinosyltransferas, concanavalin like domain	Domain
A	IPR032731	Arabinosyltransferase, C-terminal	Domain
A	IPR007680	Arabinofuranosyltransferase, central domain	Domain
A	IPR042486	Arabinosyltransferase, C-terminal, subdomain 2	Homologous Superfamily
A	IPR027451	Arabinofuranosyltransferase, domain 1	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.