3POS

Crystal structure of the globular domain of human calreticulin

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00262	e3posA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00262	ECOD (1.6)
B	PF00262	e3posB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00262	ECOD (1.6)
C	PF00262	e3posC1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00262	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
B	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
C	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Calreticulin	complement component C1q complex binding opsonin binding protein-containing complex binding protein binding binding complement binding protein-folding chaperone binding DNA binding organic cyclic compound binding nucleic acid binding RNA binding mRNA binding cation binding transition metal ion binding complement component C1q complex binding opsonin binding protein-containing complex binding protein binding binding complement binding protein-folding chaperone binding DNA binding organic cyclic compound binding nucleic acid binding RNA binding mRNA binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding molecular sequestering activity hormone binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding calcium ion binding nucleocytoplasmic carrier activity nuclear export signal receptor activity molecular carrier activity carbohydrate binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear androgen receptor binding cell adhesion molecule binding integrin binding signaling receptor binding unfolded protein binding peptide binding protein folding chaperone zinc ion binding	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation response to stimulus response to chemical response to xenobiotic stimulus spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular response to stimulus cellular response to inorganic substance cellular response to metal ion cellular response to lithium ion response to inorganic substance cellular response to chemical stimulus response to lithium ion response to metal ion regulation of protein stability regulation of biological quality protein stabilization protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process sequestering of calcium ion calcium ion homeostasis maintenance of location in cell maintenance of location cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of cellular biosynthetic process response to organic substance response to ketone response to lipid response to oxygen-containing compound response to testosterone response to organic cyclic compound heart development cardiac muscle tissue development cardiac muscle cell differentiation animal organ development muscle cell differentiation tissue development cardiocyte differentiation striated muscle tissue development circulatory system development muscle structure development striated muscle cell differentiation muscle tissue development regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death regulation of localization import into cell positive regulation of cellular component organization regulation of cellular component organization vesicle-mediated transport cellular component organization positive regulation of endocytosis phagocytosis cellular component organization or biogenesis regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis positive regulation of transport endocytosis positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading cellular response to stress response to stress cellular senescence RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription organelle organization actin cytoskeleton organization cortical actin cytoskeleton organization cortical cytoskeleton organization actin filament-based process cytoskeleton organization intracellular receptor signaling pathway negative regulation of signaling signaling regulation of signal transduction hormone-mediated signaling pathway negative regulation of cell communication cell communication negative regulation of intracellular steroid hormone receptor signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway signal transduction cellular response to organic substance cellular response to steroid hormone stimulus cellular response to hormone stimulus regulation of signaling negative regulation of response to stimulus response to endogenous stimulus cellular response to organic cyclic compound negative regulation of signal transduction steroid hormone mediated signaling pathway regulation of response to stimulus cellular response to lipid nuclear receptor signaling pathway regulation of cell communication intracellular steroid hormone receptor signaling pathway regulation of retinoic acid receptor signaling pathway negative regulation of retinoic acid receptor signaling pathway retinoic acid receptor signaling pathway protein maturation by protein folding peptide antigen assembly with MHC class I protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class I protein complex assembly cellular component biogenesis antigen processing and presentation cellular component assembly immune system process protein-containing complex assembly antigen processing and presentation of peptide antigen via MHC class I MHC protein complex assembly antigen processing and presentation of peptide antigen response to electrical stimulus cellular response to electrical stimulus response to abiotic stimulus cellular response to abiotic stimulus cellular response to environmental stimulus negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process regulation of reproductive process meiotic cell cycle process meiotic nuclear division cell cycle regulation of cell cycle cell cycle process regulation of meiotic cell cycle regulation of cell cycle process meiotic cell cycle organelle fission regulation of organelle organization regulation of meiotic nuclear division nuclear division regulation of nuclear division positive regulation of cell cycle organonitrogen compound biosynthetic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of protein metabolic process regulation of protein metabolic process translation negative regulation of gene expression regulation of translation positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration regulation of multicellular organismal process epithelial cell migration cell motility regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of dendritic cell chemotaxis regulation of response to external stimulus dendritic cell chemotaxis positive regulation of chemotaxis positive regulation of response to stimulus positive regulation of response to external stimulus taxis positive regulation of mononuclear cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process cell chemotaxis chemotaxis regulation of dendritic cell chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration response to external stimulus positive regulation of leukocyte migration positive regulation of leukocyte chemotaxis regulation of chemotaxis leukocyte migration dendritic cell migration mononuclear cell migration leukocyte chemotaxis protein folding in endoplasmic reticulum intracellular corticosteroid receptor signaling pathway intracellular glucocorticoid receptor signaling pathway cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation multi-multicellular organism process negative regulation of locomotion regulation of trophoblast cell migration female pregnancy embryo implantation negative regulation of trophoblast cell migration negative regulation of cell migration trophoblast cell migration negative regulation of reproductive process negative regulation of cell motility negative regulation of multicellular organismal process multi-organism reproductive process positive regulation of cell communication positive regulation of signal transduction regulation of non-canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette non-canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction positive regulation of non-canonical NF-kappaB signal transduction positive regulation of signaling response to glycoside protein localization to organelle protein localization to nucleus response to estradiol cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external biotic stimulus response to virus response to biotic stimulus	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system lytic vacuole cytolytic granule vacuole cytoplasm lysosome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle extracellular matrix external encapsulating structure collagen-containing extracellular matrix cytosol endoplasmic reticulum smooth endoplasmic reticulum membrane-enclosed lumen sarcoplasmic reticulum lumen intracellular organelle lumen endoplasmic reticulum lumen sarcoplasm organelle lumen sarcoplasmic reticulum intracellular vesicle phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane organelle membrane endocytic vesicle endoplasmic reticulum quality control compartment endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment protein-containing complex MHC class I peptide loading complex organelle subcompartment membrane protein complex endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane perinuclear region of cytoplasm acrosomal vesicle secretory granule secretory vesicle anchoring junction cell junction focal adhesion cell-substrate junction cortical granule intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle lumenal side of endoplasmic reticulum membrane lumenal side of membrane endocytic vesicle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C	IPR009169	Calreticulin	Family
A, B, C	IPR001580	Calreticulin/calnexin	Family
A, B, C	IPR018124	Calreticulin/calnexin, conserved site	Conserved Site
A, B, C	IPR009033	Calreticulin/calnexin, P domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P27797	essential thrombocythemia primary myelofibrosis esophageal squamous cell carcinoma Melanoma, Experimental myelofibrosis bipolar disorder prostate cancer colorectal cancer thrombocythemia 1 juvenile dermatomyositis ulcerative colitis malignant glioma aleukemic leukemia myelodysplastic syndrome Becker muscular dystrophy essential thrombocythemia primary myelofibrosis esophageal squamous cell carcinoma Melanoma, Experimental myelofibrosis bipolar disorder prostate cancer colorectal cancer thrombocythemia 1 juvenile dermatomyositis ulcerative colitis malignant glioma aleukemic leukemia myelodysplastic syndrome Becker muscular dystrophy myocardial ischemia bone marrow neoplasm cancer pancreatic ductal adenocarcinoma colorectal carcinoma coronary artery disease psoriasis Emery-Dreifuss muscular dystrophy schizoaffective disorder glioblastoma thrombocytosis disease large cell medulloblastoma medulloblastoma astrocytic tumor myopathy breast cancer osteosarcoma chromosome 19p13.13 deletion syndrome paranoid schizophrenia hematopoietic and lymphoid system neoplasm malignant ependymoma atypical teratoid rhabdoid tumor myeloproliferative neoplasm bone marrow disease breast carcinoma ovarian cancer pilocytic astrocytoma congenital anemia Duchenne muscular dystrophy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.