Annotations: 3PIN

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3pina_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	automated matches	automated matches	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d3pinb_	Alpha and beta proteins (a+b)	Ferredoxin-like	Peptide methionine sulfoxide reductase	automated matches	automated matches	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00085	e3pinA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00085	ECOD (1.6)
B	PF01625	e3pinB2	A: a+b two layers	X: Alpha-beta plaits	H: HMA-related	T: Peptide methionine sulfoxide reductase	F: PF01625	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
B	3.30.1060.10	Alpha Beta	2-Layer Sandwich	Peptide Methionine Sulfoxide Reductase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00085	Thioredoxin (Thioredoxin)	Thioredoxin	Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise.	Domain
B	PF01625	Peptide methionine sulfoxide reductase (PMSR)	Peptide methionine sulfoxide reductase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Thioredoxin-2	oxidoreductase activity, acting on a sulfur group of donors disulfide oxidoreductase activity oxidoreductase activity catalytic activity, acting on a protein protein-disulfide reductase activity catalytic activity	cellular component organization organelle organization vacuole organization organelle inheritance vacuole inheritance cellular process cellular component organization or biogenesis localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum establishment of localization Golgi vesicle transport vesicle-mediated transport cell redox homeostasis cellular component organization organelle organization vacuole organization organelle inheritance vacuole inheritance cellular process cellular component organization or biogenesis localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum establishment of localization Golgi vesicle transport vesicle-mediated transport cell redox homeostasis cellular homeostasis homeostatic process protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization organic substance metabolic process organonitrogen compound metabolic process protein deglutathionylation macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process organelle fusion vacuole fusion vacuole fusion, non-autophagic establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport glutathione metabolic process cellular metabolic process sulfur compound metabolic process amide metabolic process cellular modified amino acid metabolic process sulfate assimilation nucleotide biosynthetic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process deoxyribonucleotide biosynthetic process deoxyribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process small molecule metabolic process phosphorus metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process nucleotide metabolic process nucleobase-containing compound biosynthetic process organic cyclic compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process	membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle organelle cytoplasm Golgi membrane Golgi apparatus membrane membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle organelle cytoplasm Golgi membrane Golgi apparatus membrane endomembrane system bounding membrane of organelle organelle membrane cytosol membrane fusion priming complex protein-containing complex nucleus
B	Peptide methionine sulfoxide reductase	oxidoreductase activity, acting on a sulfur group of donors oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor L-methionine-(S)-S-oxide reductase activity L-methionine:thioredoxin-disulfide S-oxidoreductase activity catalytic activity peptide-methionine (S)-S-oxide reductase activity	cellular response to stimulus response to oxidative stress cellular response to chemical stimulus response to stimulus cellular response to stress response to stress response to chemical cellular response to oxidative stress cellular process cellular response to chemical stress	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013766	Thioredoxin domain	Domain
A	IPR005746	Thioredoxin	Family
A	IPR017937	Thioredoxin, conserved site	Conserved Site
A	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
B	IPR002569	Peptide methionine sulphoxide reductase MsrA domain	Domain
B	IPR036509	Peptide methionine sulphoxide reductase MsrA superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.