Annotations: 3PIH

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	UvrA-like	8056664	4004014	SCOP2 (2022-06-29)
A	SCOP2 Family	UvrA interaction domain-like	8056670	4007668	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056667	3001550	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8056668	3001550	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ABC transporter-like P-loop ATPases	8056665	3002020	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ABC transporter-like P-loop ATPases	8056666	3002020	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	UvrA insert domain-like	8056669	3002355	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	UvrA interaction domain-like	8056671	3002356	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17755	e3pihA4	A: alpha arrays	X: DNA-binding domain in UvrA (From Topology)	H: DNA-binding domain in UvrA (From Topology)	T: DNA-binding domain in UvrA	F: PF17755	ECOD (1.6)
A	PF17760	e3pihA2	A: a+b two layers	X: UvrB-binding domain of UvrA (From Topology)	H: UvrB-binding domain of UvrA (From Topology)	T: UvrB-binding domain of UvrA	F: PF17760	ECOD (1.6)
A	PF00005	e3pihA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00005	ECOD (1.6)
A	F_UNCLASSIFIED	e3pihA6	A: few secondary structure elements	X: DnaJ/Hsp40 cysteine-rich domain (From Topology)	H: DnaJ/Hsp40 cysteine-rich domain (From Topology)	T: DnaJ/Hsp40 cysteine-rich domain	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
A	3.30.1490.20	Alpha Beta	2-Layer Sandwich	Dna Ligase	domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17760	UvrA interaction domain (UvrA_inter)	UvrA interaction domain	This domain found in UvrA proteins interacts with the UvrB protein.	Domain
A	PF17755	UvrA DNA-binding domain (UvrA_DNA-bind)	UvrA DNA-binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	UvrABC system protein A	excinuclease ABC activity DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding excinuclease ABC activity DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides ATP-dependent activity cation binding transition metal ion binding zinc ion binding metal ion binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress metabolic process cellular process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair SOS response	protein-containing complex catalytic complex excinuclease repair complex endodeoxyribonuclease complex intracellular protein-containing complex endonuclease complex DNA repair complex intracellular anatomical structure cytoplasm cellular anatomical entity
B [auth D]	DNA (32-MER)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017871	ABC transporter-like, conserved site	Conserved Site
A	IPR013815	ATP-grasp fold, subdomain 1	Homologous Superfamily
A	IPR003439	ABC transporter-like, ATP-binding domain	Domain
A	IPR041552	UvrA DNA-binding domain	Domain
A	IPR003593	AAA+ ATPase domain	Domain
A	IPR041102	UvrA, interaction domain	Domain
A	IPR004602	UvrABC system subunit A	Family
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.