3PDY

Structure of the third and fourth spectrin repeats of the plakin domain of plectin

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3pdyA1	A: alpha bundles	X: Spectrin repeat-like	H: Spectrin repeat (From Topology)	T: Spectrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00435	e3pdyA2	A: alpha bundles	X: Spectrin repeat-like	H: Spectrin repeat (From Topology)	T: Spectrin repeat	F: PF00435	ECOD (1.6)
B	F_UNCLASSIFIED	e3pdyB2	A: alpha bundles	X: Spectrin repeat-like	H: Spectrin repeat (From Topology)	T: Spectrin repeat	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00435	e3pdyB1	A: alpha bundles	X: Spectrin repeat-like	H: Spectrin repeat (From Topology)	T: Spectrin repeat	F: PF00435	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.60	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.60	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Plectin	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding structural molecule activity structural constituent of muscle ankyrin binding cell adhesion molecule binding cadherin binding dystroglycan binding RNA binding organic cyclic compound binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding structural molecule activity structural constituent of muscle ankyrin binding cell adhesion molecule binding cadherin binding dystroglycan binding RNA binding organic cyclic compound binding nucleic acid binding structural constituent of cytoskeleton	adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization protein localization localization cellular localization cellular macromolecule localization macromolecule localization developmental process muscle structure development cellular developmental process adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization protein localization localization cellular localization cellular macromolecule localization macromolecule localization developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development myoblast differentiation tight junction organization establishment of skin barrier epithelium development skin development skin epidermis development epidermis development animal organ development tissue development regulation of vascular permeability multicellular organismal process system process circulatory system process biological regulation vascular process in circulatory system regulation of biological quality blood circulation ameboidal-type cell migration cell migration fibroblast migration cell motility cellular component biogenesis cellular component assembly cell junction assembly cell-substrate junction assembly cell-substrate junction organization hemidesmosome assembly cellular response to stimulus cellular response to stress response to stimulus response to stress response to fluid shear stress cellular response to fluid shear stress nervous system process transmission of nerve impulse cell communication anatomical structure morphogenesis cell morphogenesis protein-containing complex organization epidermal cell differentiation keratinocyte development cell development epithelial cell differentiation epithelial cell development keratinocyte differentiation intermediate filament-based process organelle organization cytoskeleton organization intermediate filament cytoskeleton organization nucleus organization multicellular organism growth developmental growth growth peripheral nervous system axon ensheathment glial cell development multicellular organism development neurogenesis gliogenesis axon ensheathment ensheathment of neurons plasma membrane organization myelination in peripheral nervous system peripheral nervous system myelin maintenance Schwann cell differentiation endomembrane system organization system development membrane organization peripheral nervous system development nervous system development myelination Schwann cell development glial cell differentiation myelin maintenance myotube cell development skeletal muscle fiber development skeletal muscle tissue development muscle cell differentiation myotube differentiation skeletal muscle organ development muscle cell development muscle tissue development muscle organ development striated muscle cell differentiation cellular response to acid chemical response to oxygen-containing compound response to water cellular response to chemical stress cellular response to oxygen-containing compound response to inorganic substance cellular response to environmental stimulus response to acid chemical cellular response to chemical stimulus cellular response to hydrostatic pressure cellular response to water stimulus response to chemical response to hydrostatic pressure response to abiotic stimulus cellular response to abiotic stimulus organic substance metabolic process biosynthetic process cellular biosynthetic process cellular metabolic process organic substance biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process response to mechanical stimulus response to external stimulus cellular response to mechanical stimulus cellular response to external stimulus wound healing response to wounding cardiac muscle cell development striated muscle tissue development cardiac cell development heart development cardiac muscle tissue development cardiac muscle cell differentiation cardiocyte differentiation circulatory system development leukocyte migration immune response immune system process leukocyte migration involved in immune response immune effector process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly skeletal myofibril assembly striated muscle cell development cellular anatomical entity morphogenesis actin filament-based process actomyosin structure organization actin cytoskeleton organization organelle assembly myofibril assembly anatomical structure formation involved in morphogenesis supramolecular fiber organization mitochondrion organization cellular respiration energy derivation by oxidation of organic compounds respiratory electron transport chain electron transport chain generation of precursor metabolites and energy cell chemotaxis chemotaxis lymphocyte chemotaxis lymphocyte migration taxis mononuclear cell migration T cell chemotaxis T cell migration leukocyte chemotaxis locomotion assembly of actomyosin apparatus involved in cytokinesis cytoskeleton-dependent cytokinesis actomyosin contractile ring assembly actomyosin contractile ring assembly actin filament organization cortical actin cytoskeleton organization cell cycle cell cycle process cortical cytoskeleton organization actin filament organization cytokinesis cytokinetic process actomyosin contractile ring organization cell division intermediate filament organization response to nutrient levels response to food sarcomere organization	intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol cell periphery sarcolemma plasma membrane membrane costamere cluster of actin-based cell projections brush border somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection perinuclear region of cytoplasm mitochondrial membrane mitochondrion organelle outer membrane intracellular membrane-bounded organelle organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane axon sarcoplasm cytoskeleton intermediate filament cytoskeleton anchoring junction cell junction focal adhesion cell-substrate junction myelin sheath hemidesmosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR041615	Desmoplakin, SH3 domain	Domain
A, B	IPR001589	Actinin-type actin-binding domain, conserved site	Conserved Site
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR049538	Plectin-like, spectrin-like repeat	Repeat
A, B	IPR035915	Plakin repeat superfamily	Homologous Superfamily
A, B	IPR001452	SH3 domain	Domain
A, B	IPR036872	CH domain superfamily	Homologous Superfamily
A, B	IPR041573	Desmoplakin, spectrin-like domain	Domain
A, B	IPR043197	Plakin	Family
A, B	IPR001101	Plectin repeat	Repeat
A, B	IPR001715	Calponin homology domain	Domain
A, B	IPR005326	Plectin/eS10, N-terminal	Domain
A, B	IPR018159	Spectrin/alpha-actinin	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q15149	epidermolysis bullosa simplex with muscular dystrophy epidermolysis bullosa simplex with nail dystrophy limb-girdle muscular dystrophy epidermolysis bullosa simplex with pyloric atresia autosomal recessive limb-girdle muscular dystrophy type 2Q junctional epidermolysis bullosa with pyloric atresia congenital myasthenic syndrome epidermolysis bullosa simplex Ogna type epidermolysis bullosa epidermolysis bullosa simplex malignant pancreatic neoplasm muscular dystrophy oligodendroglioma peripheral nervous system disease arthrogryposis epidermolysis bullosa simplex with muscular dystrophy epidermolysis bullosa simplex with nail dystrophy limb-girdle muscular dystrophy epidermolysis bullosa simplex with pyloric atresia autosomal recessive limb-girdle muscular dystrophy type 2Q junctional epidermolysis bullosa with pyloric atresia congenital myasthenic syndrome epidermolysis bullosa simplex Ogna type epidermolysis bullosa epidermolysis bullosa simplex malignant pancreatic neoplasm muscular dystrophy oligodendroglioma peripheral nervous system disease arthrogryposis bipolar I disorder glioblastoma muscle tissue disease myopathy osteoarthritis peripheral neuropathy astrocytic tumor chronic obstructive pulmonary disease Crohn disease intellectual disability malignant ependymoma muscular disease non-small cell lung carcinoma osteosarcoma congenital muscular dystrophy Epidermolysis bullosa simplex, Ogna type

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.