3P9Z

Crystal structure of uroporphyrinogen-III synthetase from Helicobacter pylori 26695

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HEM4_1	e3p9zA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Uroporphyrinogen III synthase (U3S, HemD)	F: HEM4_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10090	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02602	Uroporphyrinogen-III synthase HemD (HEM4)	Uroporphyrinogen-III synthase HemD	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Uroporphyrinogen III cosynthase (HemD)	hydro-lyase activity uroporphyrinogen-III synthase activity lyase activity catalytic activity carbon-oxygen lyase activity	pigment metabolic process heme metabolic process porphyrin-containing compound biosynthetic process organonitrogen compound metabolic process tetrapyrrole metabolic process heme biosynthetic process protoporphyrinogen IX metabolic process organonitrogen compound biosynthetic process pigment biosynthetic process organic cyclic compound metabolic process protoporphyrinogen IX biosynthetic process organic substance metabolic process tetrapyrrole biosynthetic process biosynthetic process organic cyclic compound biosynthetic process pigment metabolic process heme metabolic process porphyrin-containing compound biosynthetic process organonitrogen compound metabolic process tetrapyrrole metabolic process heme biosynthetic process protoporphyrinogen IX metabolic process organonitrogen compound biosynthetic process pigment biosynthetic process organic cyclic compound metabolic process protoporphyrinogen IX biosynthetic process organic substance metabolic process tetrapyrrole biosynthetic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process porphyrin-containing compound metabolic process oxoacid metabolic process cellular biosynthetic process uroporphyrinogen III metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process small molecule metabolic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process cellular process uroporphyrinogen III biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036108	Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily	Homologous Superfamily
A	IPR039793	Uroporphyrinogen-III synthase	Family
A	IPR003754	Tetrapyrrole biosynthesis, uroporphyrinogen III synthase	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.