3OIQ

Crystal structure of yeast telomere protein Cdc13 OB1 and the catalytic subunit of DNA polymerase alpha Pol1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nucleic acid-binding proteins	8093174	3000135	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF16853	e3oiqA1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF16853	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.50.800	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
A	1.10.10.2380	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16853	Cell division control protein 13 N-terminus (CDC13_N)	Cell division control protein 13 N-terminus	This domain is found at the N-terminus of fungal cell division control protein 13 (CDC13). It has an OB type fold. It is involved in dimerisation of CDC13 and in interaction of CDC13 with the catalytic subunit of DNA polymerase alpha, Pol1 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cell division control protein 13	sequence-specific DNA binding DNA binding G-rich strand telomeric DNA binding binding organic cyclic compound binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding nucleic acid binding telomeric DNA binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity sequence-specific DNA binding DNA binding G-rich strand telomeric DNA binding binding organic cyclic compound binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding nucleic acid binding telomeric DNA binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity telomerase inhibitor activity protein binding translation elongation factor binding identical protein binding	cellular process cell cycle cellular biosynthetic process telomere organization RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening cellular component organization nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis telomere maintenance via telomerase cellular metabolic process cellular process cell cycle cellular biosynthetic process telomere organization RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening cellular component organization nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis telomere maintenance via telomerase cellular metabolic process chromosome organization primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process telomere maintenance organic cyclic compound metabolic process organelle organization biosynthetic process organic cyclic compound biosynthetic process metabolic process macromolecule metabolic process DNA biosynthetic process regulation of telomere maintenance regulation of cellular component organization regulation of cellular process regulation of DNA biosynthetic process regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of chromosome organization regulation of macromolecule metabolic process regulation of telomere maintenance via telomere lengthening regulation of organelle organization regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process regulation of DNA metabolic process localization cellular localization ribonucleoprotein complex localization cell division telomere capping	membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus nuclear protein-containing complex chromosome cellular anatomical entity intracellular membrane-bounded organelle chromosomal region intracellular organelle organelle telomere cap complex intracellular non-membrane-bounded organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus nuclear protein-containing complex chromosome cellular anatomical entity intracellular membrane-bounded organelle chromosomal region intracellular organelle organelle telomere cap complex intracellular non-membrane-bounded organelle chromosome, telomeric repeat region CST complex chromosome, telomeric region non-membrane-bounded organelle nuclear telomere cap complex
B	DNA polymerase alpha catalytic subunit A	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding protein-containing complex binding chromatin binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding protein-containing complex binding chromatin binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding ion binding metal ion binding single-stranded DNA binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA-templated DNA replication lagging strand elongation DNA strand elongation DNA strand elongation involved in DNA replication DNA replication initiation nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA-templated DNA replication lagging strand elongation DNA strand elongation DNA strand elongation involved in DNA replication DNA replication initiation sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cellular process cell cycle cell cycle process leading strand elongation cellular biosynthetic process cellular metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process RNA-templated DNA biosynthetic process nucleic acid biosynthetic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process DNA biosynthetic process mitotic DNA replication cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process cellular response to stimulus double-strand break repair response to stimulus cellular response to stress DNA damage response response to stress DNA repair DNA synthesis involved in DNA repair	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle replication fork chromosome non-membrane-bounded organelle protein-containing complex alpha DNA polymerase:primase complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle intracellular non-membrane-bounded organelle replication fork chromosome non-membrane-bounded organelle protein-containing complex alpha DNA polymerase:primase complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome transferase complex intracellular organelle lumen nuclear replisome catalytic complex protein-DNA complex nuclear replication fork DNA polymerase complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen replisome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR031749	Cell division control protein 13, N-terminal	Domain
A	IPR011564	Telomeric single stranded DNA binding POT1/Cdc13	Domain
A	IPR028389	Protection of telomeres protein 1	Family
A	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A	IPR041028	Cdc13, OB4 dimerization domain	Domain
A	IPR040650	Cell division control protein 13, OB2 domain	Domain
B	IPR038256	DNA polymerase alpha, zinc finger domain superfamily	Homologous Superfamily
B	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
B	IPR006134	DNA-directed DNA polymerase, family B, multifunctional domain	Domain
B	IPR045846	DNA polymerase alpha catalytic subunit, catalytic domain	Domain
B	IPR017964	DNA-directed DNA polymerase, family B, conserved site	Conserved Site
B	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
B	IPR023211	DNA polymerase, palm domain superfamily	Homologous Superfamily
B	IPR015088	Zinc finger, DNA-directed DNA polymerase, family B, alpha	Domain
B	IPR006172	DNA-directed DNA polymerase, family B	Family
B	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
B	IPR006133	DNA-directed DNA polymerase, family B, exonuclease domain	Domain
B	IPR042087	DNA polymerase family B, thumb domain	Homologous Superfamily
B	IPR024647	DNA polymerase alpha catalytic subunit, N-terminal domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.