Annotations: 3NVK

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth E]	SCOP2B Superfamily	L30e-like	8033057	3001739	SCOP2B (2022-06-29)
D [auth H]	SCOP2B Superfamily	L30e-like	8033057	3001739	SCOP2B (2022-06-29)
E [auth I]	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8063654	3000118	SCOP2B (2022-06-29)
F [auth J]	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8063654	3000118	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01798	e3nvkA3	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: Nop C-terminal domain	F: PF01798	ECOD (1.6)
A	PF01798	e3nvkA2	A: alpha complex topology	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: PF01798	ECOD (1.6)
A	PF21572	e3nvkA1	A: mixed a+b and a/b	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: PF21572	ECOD (1.6)
B [auth F]	PF01798	e3nvkF3	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: Nop C-terminal domain	F: PF01798	ECOD (1.6)
B [auth F]	PF01798	e3nvkF2	A: alpha complex topology	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: PF01798	ECOD (1.6)
B [auth F]	PF21572	e3nvkF1	A: mixed a+b and a/b	X: Nop N-terminal domain (From Topology)	H: Nop N-terminal domain (From Topology)	T: Nop N-terminal domain	F: PF21572	ECOD (1.6)
C [auth E]	PF01248	e3nvkE1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: PF01248	ECOD (1.6)
D [auth H]	PF01248	e3nvkH1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: PF01248	ECOD (1.6)
E [auth I]	PF01269	e3nvkI1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF01269	ECOD (1.6)
F [auth J]	PF01269	e3nvkJ1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF01269	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.420.220	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	1.10.287.4070	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
A	1.10.246.90	Mainly Alpha	Orthogonal Bundle	Serum Albumin	Chain A, Domain 1	CATH (4.3.0)
B [auth F]	3.30.420.220	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
B [auth F]	1.10.287.4070	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
B [auth F]	1.10.246.90	Mainly Alpha	Orthogonal Bundle	Serum Albumin	Chain A, Domain 1	CATH (4.3.0)
C [auth E]	3.30.1330.30	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
D [auth H]	3.30.1330.30	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (4.3.0)
E [auth I]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
E [auth I]	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (4.3.0)
F [auth J]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
F [auth J]	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth F]	PF21572	Archaeal Nop5/56-rel, N-terminal domain (Nop5_56-rel_N_Arc)	Archaeal Nop5/56-rel, N-terminal domain	This domain is found at the N-terminal end of a group of archaeal proteins, including Uncharacterized NOP5 family protein MJ0694 from Methanocaldococcus jannaschii. This domain interacts with fibrillarin, the other subunit of a complex that is critic ...	This domain is found at the N-terminal end of a group of archaeal proteins, including Uncharacterized NOP5 family protein MJ0694 from Methanocaldococcus jannaschii. This domain interacts with fibrillarin, the other subunit of a complex that is critical to modify and process ribosomal RNAs [1-5]. This domain shows a highly conserved folded structure despite low sequence similarity among homologs. It shows four beta-sheets surrounded by four alpha- helices [6] and is found associated with Pfam:PF01798.	Domain
A, B [auth F]	PF01798	snoRNA binding domain, fibrillarin (Nop)	snoRNA binding domain, fibrillarin	-	Family
C [auth E], D [auth H]	PF01248	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].	Domain
E [auth I], F [auth J]	PF01269	Fibrillarin (Fibrillarin)	Fibrillarin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth F]	NOP5/NOP56 related protein	RNA binding binding organic cyclic compound binding snoRNA binding nucleic acid binding	-	preribosome protein-containing complex ribonucleoprotein complex small-subunit processome box C/D methylation guide snoRNP complex sno(s)RNA-containing ribonucleoprotein complex box C/D RNP complex
C [auth E], D [auth H]	50S ribosomal protein L7Ae	RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding tRNA-specific ribonuclease activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity, acting on a tRNA nuclease activity hydrolase activity, acting on ester bonds RNA endonuclease activity ribonuclease P activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity structural molecule activity structural constituent of ribosome	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing tRNA 5'-end processing cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process RNA 5'-end processing metabolic process cellular process macromolecule metabolic process tRNA 5'-leader removal ribonucleoprotein complex biogenesis rRNA processing cellular component biogenesis ribosome biogenesis cellular component organization or biogenesis rRNA metabolic process organonitrogen compound metabolic process organonitrogen compound biosynthetic process translation protein metabolic process	protein-containing complex ribonucleoprotein complex intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle
E [auth I], F [auth J]	Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase	transferase activity, transferring one-carbon groups transferase activity methyltransferase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding	methylation metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process methylation metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process cellular process macromolecule metabolic process tRNA metabolic process tRNA processing	-
G [auth K], I [auth L]	RNA (5'-R(GPCPCPGPUPUPGPAPAPGPCPUPCPUPGPAPCPCPGPAPAPAPGPGPCPGPUPGPAPUPGPAPGPC)-3')	-	-	-
H [auth G], J [auth S]	RNA (5'-R(GPAPGPCPUPUPCPAPAPCPGPGP*C)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth F]	IPR042239	Nop, C-terminal domain	Homologous Superfamily
A, B [auth F]	IPR036070	Nop domain superfamily	Homologous Superfamily
A, B [auth F]	IPR045056	Nucleolar protein Nop56/Nop58	Family
A, B [auth F]	IPR002687	Nop domain	Domain
A, B [auth F]	IPR029012	Helix hairpin bin domain superfamily	Homologous Superfamily
A, B [auth F]	IPR048896	Nop5/56-related, N-terminal domain	Domain
A, B [auth F]	IPR012976	NOSIC	Domain
A, B [auth F]	IPR047099	Nop5, N-terminal domain superfamily	Homologous Superfamily
C [auth E], D [auth H]	IPR004038	Ribosomal protein eL8/eL30/eS12/Gadd45	Domain
C [auth E], D [auth H]	IPR022481	Large ribosomal subunit protein eL8, archaea	Family
C [auth E], D [auth H]	IPR004037	Large ribosomal subunit protein eL8-like, conserved site	Conserved Site
C [auth E], D [auth H]	IPR029064	Ribosomal protein eL30-like superfamily	Homologous Superfamily
C [auth E], D [auth H]	IPR018492	Ribosomal protein eL8/Nhp2 family	Family
E [auth I], F [auth J]	IPR000692	rRNA 2'-O-methyltransferase fibrillarin-like	Family
E [auth I], F [auth J]	IPR020813	Fibrillarin, conserved site	Conserved Site
E [auth I], F [auth J]	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.