3NTW

Structure of the MLLE domain of EDD in complex with a PAM2 peptide from Paip1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3ntwa1	All alpha proteins	PABP domain-like	PABC (PABP) domain	PABC (PABP) domain	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d3ntwa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d3ntwc_	All alpha proteins	PABP domain-like	PABC (PABP) domain	PABC (PABP) domain	automated matches	Rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PABC (PABP) domain	8068211	4003044	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PABC (PABP) domain	8068212	3000200	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	PABC (PABP) domain	8068212	3000200	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PABP	e3ntwA1	A: alpha arrays	X: PABP domain-like	H: PABC(PABP) domain (From Topology)	T: PABC(PABP) domain	F: PABP	ECOD (1.6)
C	PABP	e3ntwC1	A: alpha arrays	X: PABP domain-like	H: PABC(PABP) domain (From Topology)	T: PABC(PABP) domain	F: PABP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1900.10	Mainly Alpha	Orthogonal Bundle	c-terminal domain of poly(a) binding protein	c-terminal domain of poly(a) binding protein	CATH (4.3.0)
C	1.10.1900.10	Mainly Alpha	Orthogonal Bundle	c-terminal domain of poly(a) binding protein	c-terminal domain of poly(a) binding protein	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00658	Poly-adenylate binding protein, unique domain (PABP)	Poly-adenylate binding protein, unique domain	-	Family
B, D	PF07145	Ataxin-2 C-terminal region (PAM2)	Ataxin-2 C-terminal region	-	Motif

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	E3 ubiquitin-protein ligase UBR5	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding protein domain specific binding ubiquitin binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity protein binding binding protein domain specific binding ubiquitin binding ubiquitin-like protein binding RNA binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process heterochromatin boundary formation regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process heterochromatin boundary formation regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process heterochromatin organization regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of gene expression positive regulation of cellular biosynthetic process DNA repair-dependent chromatin remodeling organonitrogen compound metabolic process primary metabolic process protein ubiquitination macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization regulation of localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization localization import into nucleus cellular macromolecule localization establishment of localization in cell regulation of intracellular transport positive regulation of protein localization to nucleus organic substance transport positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport cellular localization regulation of protein localization transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport regulation of cellular localization protein transport macromolecule localization protein localization to organelle protein polyubiquitination regulation of protein stability regulation of biological quality DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA repair protein K48-linked ubiquitination response to organic substance intracellular receptor signaling pathway response to lipid signaling progesterone receptor signaling pathway hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone signal transduction cellular response to organic substance cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus response to endogenous stimulus cellular response to organic cyclic compound cellular response to chemical stimulus steroid hormone mediated signaling pathway response to chemical cellular response to lipid nuclear receptor signaling pathway intracellular steroid hormone receptor signaling pathway multicellular organismal process cytokine production regulation of cytokine production regulation of multicellular organismal process interleukin-17 production negative regulation of interleukin-17 production negative regulation of cytokine production regulation of interleukin-17 production negative regulation of multicellular organismal process positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling	intracellular anatomical structure cytoplasm cellular anatomical entity protein-containing complex perinuclear region of cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B, D	Polyadenylate-binding protein-interacting protein 1	translation regulator activity translation activator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding RNA binding	viral gene expression viral process viral translation regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process viral gene expression viral process viral translation regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process positive regulation of mRNA metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of RNA metabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay catabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process macromolecule catabolic process mRNA destabilization negative regulation of mRNA metabolic process regulation of mRNA catabolic process organic substance metabolic process positive regulation of biosynthetic process negative regulation of cellular process regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of catabolic process RNA destabilization nuclear-transcribed mRNA catabolic process biological regulation negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process regulation of cellular biosynthetic process regulation of mRNA stability positive regulation of catabolic process negative regulation of biosynthetic process positive regulation of gene expression positive regulation of mRNA catabolic process regulation of RNA stability cellular process regulation of mRNA metabolic process organic substance catabolic process positive regulation of cellular biosynthetic process organonitrogen compound metabolic process organonitrogen compound biosynthetic process translation translational initiation protein metabolic process mRNA stabilization CRD-mediated mRNA stabilization RNA stabilization positive regulation of protein metabolic process positive regulation of translation positive regulation of cytoplasmic translation regulation of protein metabolic process regulation of translation cytoplasmic translation regulation of cytoplasmic translation regulation of translational initiation modulation by host of viral process biological process involved in interspecies interaction between organisms modulation by host of symbiont process positive regulation by host of viral process biological process involved in interaction with symbiont biological process involved in symbiotic interaction	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol mCRD-mediated mRNA stability complex protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR035983	HECT, E3 ligase catalytic domain	Homologous Superfamily
A, C	IPR002004	Polyadenylate-binding protein/Hyperplastic disc protein	Domain
A, C	IPR024725	E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain	Domain
A, C	IPR000569	HECT domain	Domain
A, C	IPR003126	Zinc finger, UBR-type	Domain
A, C	IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	Homologous Superfamily
A, C	IPR047503	E3 ubiquitin-protein ligase UBR5, UBR-box	Domain
A, C	IPR036053	PABC (PABP) domain	Homologous Superfamily
B, D	IPR016024	Armadillo-type fold	Homologous Superfamily
B, D	IPR003890	MIF4G-like, type 3	Domain
B, D	IPR009818	Ataxin-2, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D	Pharos: Q9H074	astrocytic tumor glioblastoma lung adenocarcinoma malignant glioma oligodendroglioma tuberculosis breast cancer interstitial cystitis lung cancer nasopharyngeal carcinoma pilocytic astrocytoma ductal breast carcinoma in situ invasive ductal breast carcinoma malignant ependymoma non-small cell lung carcinoma astrocytic tumor glioblastoma lung adenocarcinoma malignant glioma oligodendroglioma tuberculosis breast cancer interstitial cystitis lung cancer nasopharyngeal carcinoma pilocytic astrocytoma ductal breast carcinoma in situ invasive ductal breast carcinoma malignant ependymoma non-small cell lung carcinoma plasma cell myeloma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.