3NO8

Crystal structure of the PHR domain from human BTBD2 Protein

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PHR	e3no8A1	A: beta sandwiches	X: jelly-roll	H: PHR domain (From Topology)	T: PHR domain	F: PHR	ECOD (1.6)
B	PHR	e3no8B1	A: beta sandwiches	X: jelly-roll	H: PHR domain (From Topology)	T: PHR domain	F: PHR	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.820	Mainly Beta	Sandwich	Jelly Rolls	PHR domain	CATH (4.3.0)
B	2.60.120.820	Mainly Beta	Sandwich	Jelly Rolls	PHR domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08005	PHR domain (PHR)	PHR domain	This domain is called PHR as it was original found in the proteins PAM (Swiss:O75592), highwire (Swiss:Q9NB71) and RPM (Swiss:Q17551) [1]. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of ...	This domain is called PHR as it was original found in the proteins PAM (Swiss:O75592), highwire (Swiss:Q9NB71) and RPM (Swiss:Q17551) [1]. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	BTB/POZ domain-containing protein 2	-	developmental process neurogenesis multicellular organism development multicellular organismal process cellular developmental process cell differentiation anatomical structure development cellular process nervous system development system development	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle supramolecular complex P-body non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011705	BTB/Kelch-associated	Domain
A, B	IPR012983	PHR	Domain
A, B	IPR000210	BTB/POZ domain	Domain
A, B	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
A, B	IPR038648	PHR domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9BX70	atypical teratoid rhabdoid tumor large cell medulloblastoma glioblastoma interstitial cystitis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.