3NMO

Crystal structure of an engineered monomeric CLC-ec1 Cl-/H+ transporter

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3nmoa_	Membrane and cell surface proteins and peptides	Clc chloride channel	Clc chloride channel	Clc chloride channel	automated matches	(Escherichia coli 042 ) [TaxId: 216592 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Clc chloride channel	8034333	3000511	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Voltage_CLC	e3nmoA1	A: alpha complex topology	X: Clc chloride channel (From Topology)	H: Clc chloride channel (From Topology)	T: Clc chloride channel	F: Voltage_CLC	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.3080.10	Mainly Alpha	Orthogonal Bundle	Clc chloride channel	Clc chloride channel	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00654	Voltage gated chloride channel (Voltage_CLC)	Voltage gated chloride channel	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	H(+)/Cl(-) exchange transporter clcA	voltage-gated chloride channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic anion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity voltage-gated chloride channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic anion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic anion channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity identical protein binding protein binding binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity chloride:proton antiporter activity inorganic cation transmembrane transporter activity solute:inorganic anion antiporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular response to stimulus response to stimulus transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular response to stimulus response to stimulus cellular response to chemical stress response to acidic pH cellular stress response to acidic pH cellular response to environmental stimulus cellular response to chemical stimulus cellular response to stress response to pH response to stress response to chemical cellular response to pH response to abiotic stimulus cellular response to acidic pH cellular response to abiotic stimulus inorganic anion transmembrane transport chloride transport chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport inorganic anion transport	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR014743	Chloride channel, core	Homologous Superfamily
A	IPR023861	Chloride channel, ClcA	Family
A	IPR001807	Chloride channel, voltage gated	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	H⁺/Cl^- or F^- Exchange Transporters	Monomeric H⁺/Cl^- Exchange Transporter (CLC-ec1)

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.