3NFI

Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d3nfid2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, C-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D	d3nfid1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, N-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
E	d3nfie2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, C-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
E	d3nfie1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, N-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
A	d3nfia2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, C-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
A	d3nfia1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, N-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d3nfib2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, C-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d3nfib1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, N-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d3nfic2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, C-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d3nfic1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	RNA polymerase I subunit A49, winged helix domain	RNA polymerase I subunit A49, winged helix domain, N-terminal domain	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PF06870	e3nfiD1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF06870	ECOD (1.6)
E	PF06870	e3nfiE1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF06870	ECOD (1.6)
A	PF06870	e3nfiA1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF06870	ECOD (1.6)
B	PF06870	e3nfiB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF06870	ECOD (1.6)
C	PF06870	e3nfiC1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF06870	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF06870	A49-like RNA polymerase I associated factor (RNA_pol_I_A49)	A49-like RNA polymerase I associated factor	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	DNA-directed RNA polymerase I subunit RPA49	DNA binding binding organic cyclic compound binding nucleic acid binding DNA-directed 5'-3' RNA polymerase activity 5'-3' RNA polymerase activity RNA polymerase I activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process organic substance metabolic process transcription by RNA polymerase I rRNA transcription organic substance biosynthetic process rRNA metabolic process nucleolar large rRNA transcription by RNA polymerase I cellular metabolic process primary metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process organic substance metabolic process transcription by RNA polymerase I rRNA transcription organic substance biosynthetic process rRNA metabolic process nucleolar large rRNA transcription by RNA polymerase I cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process DNA-templated transcription termination termination of RNA polymerase I transcription cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular component organization or biogenesis cellular component organization regulation of cellular component size biological regulation regulation of biological quality regulation of cell size regulation of anatomical structure size transcription preinitiation complex assembly RNA polymerase I preinitiation complex assembly protein-DNA complex organization transcription initiation at RNA polymerase I promoter cellular component assembly protein-containing complex assembly protein-containing complex organization protein-DNA complex assembly DNA-templated transcription initiation transcription elongation by RNA polymerase I DNA-templated transcription elongation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex RNA polymerase I complex nuclear protein-containing complex transferase complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR009668	RNA polymerase I associated factor, A49-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.