3N50

Human Early B-cell factor 3 (EBF3) IPT/TIG and HLHLH domains

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8052693	3001962	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	E set domains	8052694	3000070	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8052693	3001962	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	E set domains	8052694	3000070	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	E set domains	8052694	3000070	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8052693	3001962	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8052693	3001962	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	E set domains	8052694	3000070	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	E set domains	8052694	3000070	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8052693	3001962	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8052693	3001962	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	E set domains	8052694	3000070	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01833,PF16423	e3n50A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF01833,PF16423	ECOD (1.6)
B	PF01833,PF16423	e3n50B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF01833,PF16423	ECOD (1.6)
C	PF01833,PF16423	e3n50C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF01833,PF16423	ECOD (1.6)
D	PF01833,PF16423	e3n50D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF01833,PF16423	ECOD (1.6)
E	PF01833,PF16423	e3n50E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF01833,PF16423	ECOD (1.6)
F	PF01833,PF16423	e3n50F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF01833,PF16423	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	1.10.287.4280	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	1.10.287.4280	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	1.10.287.4280	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	1.10.287.4280	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
F	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F	1.10.287.4280	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01833	IPT/TIG domain (TIG)	IPT/TIG domain	This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family d ...	This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognise a significant number of members.	Domain
A, B, C, D, E A, B, C, D, E, F	PF16423	Transcription factor COE1 helix-loop-helix domain (COE1_HLH)	Transcription factor COE1 helix-loop-helix domain	This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerisation [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Transcription factor COE3	DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding cation binding ion binding metal ion binding small molecule binding	regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular process positive regulation of cellular biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II	intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR032200	Transcription factor COE, DNA-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR002909	IPT domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR018350	Transcription factor COE, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR038173	Transcription factor COE, DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR003523	Transcription factor COE	Family
A, B, C, D, E A, B, C, D, E, F	IPR032201	Transcription factor COE, helix-loop-helix domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR038006	Transcription factor COE, IPT domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9H4W6	hypotonia, ataxia, and delayed development syndrome intellectual disability breast carcinoma invasive ductal breast carcinoma medulloblastoma primitive neuroectodermal tumor breast fibroadenoma large cell medulloblastoma Mobius syndrome ductal breast carcinoma in situ interstitial cystitis lung carcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.