Annotations: 3MZL

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054126	3002276	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054126	3002276	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054126	3002276	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Coat and nuclear envelope proteins	8054126	3002276	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00400	e3mzlA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
C	PF00400	e3mzlC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
E	PF00400	e3mzlE1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
G	PF00400	e3mzlG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
B	PF12931	e3mzlB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: PF12931	ECOD (1.6)
H	PF12931	e3mzlH1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: PF12931	ECOD (1.6)
D	PF12931	e3mzlD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: PF12931	ECOD (1.6)
F	PF12931	e3mzlF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain (From Topology)	T: Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	F: PF12931	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
E	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
G	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	2.20.25.400	Mainly Beta	Single Sheet	N-terminal domain of TfIIb		CATH (4.3.0)
B	6.10.140.1600	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
B	1.25.40.980	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
H	2.20.25.400	Mainly Beta	Single Sheet	N-terminal domain of TfIIb		CATH (4.3.0)
H	6.10.140.1600	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
H	1.25.40.980	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
D	2.20.25.400	Mainly Beta	Single Sheet	N-terminal domain of TfIIb		CATH (4.3.0)
D	6.10.140.1600	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
D	1.25.40.980	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
F	2.20.25.400	Mainly Beta	Single Sheet	N-terminal domain of TfIIb		CATH (4.3.0)
F	6.10.140.1600	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
F	1.25.40.980	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
B, D, F, H	PF12931	Sec23-binding domain of Sec16 (Sec16_C)	Sec23-binding domain of Sec16	Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Protein transport protein SEC13	structural molecule activity	cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization regulation of localization regulation of cellular process transport positive regulation of biological process cellular component organization localization nuclear pore localization cellular localization nucleus organization organelle organization cellular process localization within membrane cellular component organization or biogenesis protein-containing complex localization regulation of localization regulation of cellular process transport positive regulation of biological process positive regulation of ER to Golgi vesicle-mediated transport vesicle-mediated transport establishment of localization in cell positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of biological process regulation of ER to Golgi vesicle-mediated transport regulation of transport biological regulation intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport regulation of vesicle-mediated transport establishment of localization positive regulation of transport regulation of cellular localization Golgi vesicle transport protein localization protein exit from endoplasmic reticulum establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport membrane organization vesicle budding from membrane vesicle organization COPII-coated vesicle budding RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction TOR signaling regulation of signaling regulation of TOR signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling nucleocytoplasmic transport nuclear transport regulation of TORC1 signaling TORC1 signaling protein localization to nucleus import into nucleus establishment of protein localization to organelle protein localization to organelle protein import into nucleus regulation of protein exit from endoplasmic reticulum regulation of protein localization positive regulation of establishment of protein localization positive regulation of protein transport regulation of establishment of protein localization regulation of protein transport positive regulation of protein exit from endoplasmic reticulum positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport positive regulation of TORC1 signaling positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle cellular anatomical entity endomembrane system intracellular organelle organelle envelope organelle nuclear envelope nuclear pore membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex nuclear pore outer ring intracellular membrane-bounded organelle cellular anatomical entity endomembrane system intracellular organelle organelle envelope organelle nuclear envelope nuclear pore cell periphery vesicle coat intracellular vesicle transport vesicle membrane membrane protein complex membrane coat bounding membrane of organelle vesicle membrane cytoplasmic vesicle ER to Golgi transport vesicle membrane coated vesicle vesicle transport vesicle membrane coated membrane COPII vesicle coat cytoplasmic vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle cytoplasm organelle membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane Seh1-associated complex vacuolar membrane vacuole
B, D, F, H	Protein transport protein SEC31	structural molecule activity	cellular component organization organelle organization cellular process cellular component organization or biogenesis endoplasmic reticulum organization endomembrane system organization protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization cellular component organization organelle organization cellular process cellular component organization or biogenesis endoplasmic reticulum organization endomembrane system organization protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport regulation of localization regulation of cellular process positive regulation of biological process positive regulation of ER to Golgi vesicle-mediated transport vesicle-mediated transport positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of biological process regulation of ER to Golgi vesicle-mediated transport regulation of transport biological regulation endoplasmic reticulum to Golgi vesicle-mediated transport regulation of vesicle-mediated transport positive regulation of transport regulation of cellular localization Golgi vesicle transport membrane organization vesicle budding from membrane vesicle organization COPII-coated vesicle budding vesicle cargo loading COPII-coated vesicle cargo loading regulation of protein exit from endoplasmic reticulum protein exit from endoplasmic reticulum regulation of protein localization positive regulation of establishment of protein localization positive regulation of protein transport regulation of establishment of protein localization regulation of protein transport positive regulation of protein exit from endoplasmic reticulum positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum exit site endoplasmic reticulum cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cell projection mating projection cell tip mating projection tip membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum exit site endoplasmic reticulum cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection site of polarized growth protein-containing complex vesicle coat intracellular vesicle transport vesicle membrane membrane protein complex membrane coat bounding membrane of organelle vesicle membrane cytoplasmic vesicle ER to Golgi transport vesicle membrane coated vesicle vesicle transport vesicle membrane coated membrane COPII vesicle coat cytoplasmic vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle organelle membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, C, E, G	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, C, E, G	IPR037363	Sec13/Seh1 family	Family
A, C, E, G	IPR001680	WD40 repeat	Repeat
B, D, F, H	IPR021614	Protein transport protein SEC31	Family
B, D, F, H	IPR019775	WD40 repeat, conserved site	Conserved Site
B, D, F, H	IPR040251	Protein transport protein SEC31-like	Family
B, D, F, H	IPR009917	SRA1/Sec31	Domain
B, D, F, H	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B, D, F, H	IPR001680	WD40 repeat	Repeat
B, D, F, H	IPR024298	Ancestral coatomer element 1, Sec16/Sec31	Domain
B, D, F, H	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.