3MP7

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3mp7a1	Membrane and cell surface proteins and peptides	Preprotein translocase SecY subunit	Preprotein translocase SecY subunit	automated matches	automated matches	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
A	d3mp7a2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SecY-like	8045134	4001751	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SecY-like	8056968	3000333	SCOP2 (2022-06-29)
B	SCOP2 Family	Protein translocase subunit SecE-like	8100257	4005885	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Protein translocase subunit SecE-like	8100258	3002174	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SecY	e3mp7A2	A: alpha complex topology	X: Preprotein translocase SecY subunit (From Topology)	H: Preprotein translocase SecY subunit (From Topology)	T: Preprotein translocase SecY subunit	F: SecY	ECOD (1.6)
B	SecE_1	e3mp7B1	A: extended segments	X: Preprotein translocase SecE subunit (From Topology)	H: Preprotein translocase SecE subunit (From Topology)	T: Preprotein translocase SecE subunit	F: SecE_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.3370.10	Mainly Alpha	Orthogonal Bundle	Preprotein translocase SecY subunit	SecY subunit domain	CATH (4.3.0)
B	1.20.5.820	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Preprotein translocase SecE subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10559	Plug domain of Sec61p (Plug_translocon)	Plug domain of Sec61p	The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unl ...	The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74 [1].	Domain
A	PF00344	SecY (SecY)	SecY	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Preprotein translocase subunit secY	-	protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport intracellular protein transmembrane transport organic substance transport intracellular transport protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport intracellular protein transmembrane transport organic substance transport intracellular transport transmembrane transport protein transmembrane transport protein transport establishment of localization in cell intracellular protein transport	cell periphery plasma membrane membrane cellular anatomical entity
B	Preprotein translocase subunit secE	macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity	protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion protein localization to extracellular region secretion by cell protein transport intracellular protein transmembrane transport intracellular transport transmembrane transport protein transmembrane transport establishment of localization in cell intracellular protein transport	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002208	SecY/SEC61-alpha family	Family
A	IPR030659	SecY conserved site	Conserved Site
A	IPR026593	Protein translocase subunit SecY	Family
A	IPR019561	Translocon Sec61/SecY, plug domain	Domain
A	IPR023201	SecY domain superfamily	Homologous Superfamily
B	IPR008158	Protein translocase SEC61 complex, gamma subunit	Family
B	IPR001901	Protein translocase complex, SecE/Sec61-gamma subunit	Family
B	IPR023391	Protein translocase SecE domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	General secretory pathway (Sec)	Protein translocase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Sec, Translocase, and Insertase Proteins	SecYEβ "primed" translocon

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.