Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATransketolase_Ce3mosA6 A: a/b three-layered sandwichesX: TK C-terminal domain-like (From Topology)H: TK C-terminal domain-like (From Topology)T: TK C-terminal domain-likeF: Transketolase_CECOD (1.6)
ATransketolase_Ne3mosA4 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: Transketolase_NECOD (1.6)
ATransket_pyre3mosA5 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: Transket_pyrECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (4.3.0)
A3.40.50.920 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02779Transketolase, pyrimidine binding domain (Transket_pyr)Transketolase, pyrimidine binding domainThis family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.Domain
PF02780Transketolase, C-terminal domain (Transketolase_C)Transketolase, C-terminal domainThe C-terminal domain of transketolase has been proposed as a regulatory molecule binding site [2].Domain
PF00456Transketolase, thiamine diphosphate binding domain (Transketolase_N)Transketolase, thiamine diphosphate binding domainThis family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common ...This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Transketolase