Annotations: 3MOP

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G	SCOP2 Family	DEATH domain DD	8087387	4000378	SCOP2 (2022-06-29)
G	SCOP2 Superfamily	DEATH domain	8087388	3000069	SCOP2 (2022-06-29)
H	SCOP2B Superfamily	DEATH domain	8087388	3000069	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	DEATH domain	8087388	3000069	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	DEATH domain	8087388	3000069	SCOP2B (2022-06-29)
A	SCOP2 Family	DEATH domain DD	8084422	4000378	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DEATH domain	8084423	3000069	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	DEATH domain	8084423	3000069	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	DEATH domain	8084423	3000069	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	DEATH domain	8084423	3000069	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	DEATH domain	8084423	3000069	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	DEATH domain	8084423	3000069	SCOP2B (2022-06-29)
K	SCOP2 Family	DEATH domain DD	8084420	4000378	SCOP2 (2022-06-29)
K	SCOP2 Superfamily	DEATH domain	8084421	3000069	SCOP2 (2022-06-29)
L	SCOP2B Superfamily	DEATH domain	8084421	3000069	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	DEATH domain	8084421	3000069	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	DEATH domain	8084421	3000069	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G	Death	e3mopG1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
H	Death	e3mopH1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
I	Death	e3mopI1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
J	Death	e3mopJ1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
A	Death	e3mopA1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
B	Death	e3mopB1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
C	Death	e3mopC1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
D	Death	e3mopD1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
E	Death	e3mopE1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
F	Death	e3mopF1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
K	Death	e3mopK1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
L	Death	e3mopL1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
M	Death	e3mopM1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)
N	Death	e3mopN1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
G	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
H	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
I	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
J	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
A	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
B	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
C	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
D	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
E	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
F	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
K	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
L	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
M	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)
N	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00531	Death domain (Death)	Death domain	-	Domain
K, L, M, N	PF00531	Death domain (Death)	Death domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
G, H, I, J	Interleukin-1 receptor-associated kinase 4	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups catalytic activity, acting on a protein protein kinase activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups catalytic activity, acting on a protein protein kinase activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein binding interleukin-1 receptor binding signaling receptor binding cytokine receptor binding growth factor receptor binding kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity	cellular response to stimulus positive regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway response to stimulus response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process cellular response to stimulus positive regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway response to stimulus response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process immune response response to other organism regulation of innate immune response response to external stimulus regulation of response to stimulus defense response to other organism positive regulation of defense response toll-like receptor 9 signaling pathway activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process positive regulation of response to stimulus endolysosomal toll-like receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response response to external biotic stimulus positive regulation of innate immune response defense response biological regulation defense response to symbiont immune system process cellular process response to organic substance cell surface receptor signaling pathway response to cytokine cytokine-mediated signaling pathway cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway immune response-regulating cell surface receptor signaling pathway cell surface toll-like receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway toll-like receptor 4 signaling pathway neutrophil mediated immunity leukocyte mediated immunity myeloid leukocyte mediated immunity immune effector process interleukin-33-mediated signaling pathway response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus response to bacterium cellular response to lipid response to molecule of bacterial origin Toll signaling pathway JNK cascade MAPK cascade leukocyte migration myeloid leukocyte migration cell migration neutrophil migration cell motility granulocyte migration cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process cellular response to interleukin-1 interleukin-1-mediated signaling pathway response to interleukin-1	cell surface cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane endosome membrane membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system cell surface cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane endosome membrane membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle vesicle organelle membrane extrinsic component of plasma membrane extrinsic component of membrane extracellular region extracellular space nucleus
A, B, C, D, E A, B, C, D, E, F	Myeloid differentiation primary response protein MyD88	protein binding binding signaling receptor binding Toll-like receptor binding catalytic activity, acting on a protein catalytic activity, acting on a nucleic acid histone chaperone activity ATP-dependent activity ATP-dependent activity, acting on DNA ATP-dependent chromatin remodeler activity catalytic activity, acting on DNA protein carrier chaperone ATP-dependent histone chaperone activity catalytic activity protein binding binding signaling receptor binding Toll-like receptor binding catalytic activity, acting on a protein catalytic activity, acting on a nucleic acid histone chaperone activity ATP-dependent activity ATP-dependent activity, acting on DNA ATP-dependent chromatin remodeler activity catalytic activity, acting on DNA protein carrier chaperone ATP-dependent histone chaperone activity catalytic activity molecular carrier activity Toll binding interleukin-1 receptor binding cytokine receptor binding growth factor receptor binding TIR domain binding protein domain specific binding tumor necrosis factor receptor superfamily binding death receptor binding molecular adaptor activity identical protein binding protein-macromolecule adaptor activity signaling adaptor activity	regulation of biological process regulation of cell motility regulation of cellular process regulation of leukocyte migration biological regulation neutrophil migration granulocyte migration leukocyte migration immune system process regulation of locomotion myeloid leukocyte migration regulation of cell migration cell migration cellular process regulation of biological process regulation of cell motility regulation of cellular process regulation of leukocyte migration biological regulation neutrophil migration granulocyte migration leukocyte migration immune system process regulation of locomotion myeloid leukocyte migration regulation of cell migration cell migration cellular process regulation of immune system process cell motility regulation of neutrophil migration locomotion adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity response to stimulus immune response B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process cellular response to stimulus regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms pattern recognition receptor signaling pathway regulation of response to external stimulus toll-like receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway MyD88-dependent toll-like receptor signaling pathway positive regulation of innate immune response defense response response to other organism regulation of innate immune response defense response to symbiont response to external stimulus regulation of response to stimulus defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response response to organic substance response to endogenous stimulus response to organonitrogen compound response to lipoprotein particle response to nitrogen compound cellular response to low-density lipoprotein particle stimulus cellular response to oxidised low-density lipoprotein particle stimulus response to chemical cellular response to lipoprotein particle stimulus localization import into cell transport phagocytosis endocytosis establishment of localization vesicle-mediated transport cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cell surface receptor signaling pathway interleukin-33-mediated signaling pathway response to cytokine cytokine-mediated signaling pathway cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to organic substance apoptotic process cell death programmed cell death developmental process epithelium development endothelial cell differentiation cellular developmental process endothelium development cell development tissue development epithelial cell differentiation endothelial cell development establishment of endothelial intestinal barrier epithelial cell development cell differentiation establishment of endothelial barrier anatomical structure development Toll signaling pathway multicellular organismal process chemokine (C-X-C motif) ligand 2 production regulation of chemokine (C-X-C motif) ligand 2 production regulation of cytokine production cytokine production regulation of multicellular organismal process regulation of chemokine production chemokine production defense response to bacterium response to bacterium interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production positive regulation of multicellular organismal process positive regulation of cytokine production positive regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade regulation of cell communication positive regulation of signaling defense response to protozoan response to protozoan positive regulation of chemokine production positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function organic cyclic compound metabolic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation positive regulation of mononuclear cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation cell activation positive regulation of lymphocyte proliferation regulation of cell population proliferation mononuclear cell proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation regulation of immune effector process regulation of cytokine production involved in immune response regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response positive regulation of cytokine production involved in immune response macrophage cytokine production leukocyte activation involved in inflammatory response inflammatory response induced systemic resistance negative regulation of biological process negative regulation of cellular metabolic process post-transcriptional regulation of gene expression negative regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA stabilization mRNA catabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process negative regulation of gene expression negative regulation of macromolecule biosynthetic process nucleic acid catabolic process negative regulation of RNA metabolic process catabolic process macromolecule catabolic process negative regulation of mRNA metabolic process 3'-UTR-mediated mRNA stabilization regulation of mRNA catabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of catabolic process negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of catabolic process mRNA metabolic process organic cyclic compound catabolic process regulation of mRNA stability RNA stabilization negative regulation of biosynthetic process regulation of RNA stability regulation of mRNA metabolic process organic substance catabolic process toll-like receptor 8 signaling pathway cytoplasmic pattern recognition receptor signaling pathway intracellular receptor signaling pathway endolysosomal toll-like receptor signaling pathway defense response to virus response to virus positive regulation of type I interferon production type I interferon production regulation of type I interferon production transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process response to molecule of fungal origin response to fungus interferon-mediated signaling pathway cellular response to type I interferon type I interferon-mediated signaling pathway response to type I interferon response to acid chemical response to amino acid positive regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction immune response-regulating cell surface receptor signaling pathway cell surface toll-like receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway toll-like receptor 4 signaling pathway skin development animal organ development interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production neutrophil-mediated killing of symbiont cell disruption of cell in another organism myeloid leukocyte mediated immunity biological process involved in symbiotic interaction neutrophil mediated immunity biological process involved in interaction with symbiont killing of cells of another organism neutrophil-mediated killing of bacterium neutrophil mediated cytotoxicity leukocyte mediated cytotoxicity killing by host of symbiont cells disruption of anatomical structure in another organism cell killing response to lipid cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to lipid response to molecule of bacterial origin response to interleukin-1 myeloid leukocyte differentiation hemopoiesis macrophage differentiation mononuclear cell differentiation nervous system development multicellular organism development neurogenesis central nervous system development gliogenesis glial cell differentiation myeloid cell differentiation microglia differentiation system development leukocyte differentiation response to alcohol response to ethanol regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly cellular component biogenesis cellular component assembly inflammasome-mediated signaling pathway canonical inflammasome complex assembly positive regulation of pattern recognition receptor signaling pathway positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly regulation of cellular component organization positive regulation of cellular component organization regulation of cytoplasmic pattern recognition receptor signaling pathway cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis regulation of inflammatory response response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus positive regulation of interleukin-23 production interleukin-23 production regulation of interleukin-23 production interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production cellular response to interleukin-1 interleukin-1-mediated signaling pathway regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to organic cyclic compound response to peptidoglycan chemokine (C-X-C motif) ligand 1 production regulation of chemokine (C-X-C motif) ligand 1 production response to amine defense response to Gram-positive bacterium neutrophil activation cell activation involved in immune response myeloid leukocyte activation myeloid cell activation involved in immune response neutrophil activation involved in immune response leukocyte activation involved in immune response granulocyte activation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane endosome membrane intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane endosome membrane membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle vesicle organelle membrane cell surface protein-containing complex nucleus
K, L, M, N	Interleukin-1 receptor-associated kinase-like 2	protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity protein heterodimerization activity protein binding binding protein dimerization activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity protein heterodimerization activity protein binding binding protein dimerization activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein homodimerization activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction regulation of defense response positive regulation of response to biotic stimulus cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms pattern recognition receptor signaling pathway regulation of response to external stimulus toll-like receptor signaling pathway positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process innate immune response-activating signaling pathway MyD88-dependent toll-like receptor signaling pathway positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response immune response-regulating cell surface receptor signaling pathway cell surface toll-like receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway cell surface receptor signaling pathway toll-like receptor 4 signaling pathway response to organic substance response to lipid cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium cellular response to organic substance response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical cellular response to lipid response to molecule of bacterial origin response to cytokine response to interleukin-1 Toll signaling pathway cellular biosynthetic process negative regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process negative regulation of NF-kappaB transcription factor activity nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process negative regulation of molecular function primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of molecular function regulation of signal transduction cytokine-mediated signaling pathway cellular response to cytokine stimulus regulation of signaling regulation of cytokine-mediated signaling pathway regulation of response to cytokine stimulus regulation of cell communication protein phosphorylation organonitrogen compound metabolic process phosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process cellular response to interleukin-1 interleukin-1-mediated signaling pathway inflammatory response	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane endosome membrane membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane endosome membrane membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle vesicle organelle membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
G, H, I, J	IPR017428	Interleukin-1 receptor-associated kinase 4	Family
G, H, I, J	IPR000719	Protein kinase domain	Domain
G, H, I, J	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
G, H, I, J	IPR011029	Death-like domain superfamily	Homologous Superfamily
G, H, I, J	IPR037970	IRAK4, Death domain	Domain
G, H, I, J	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR000488	Death domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011029	Death-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR034249	MyD88, death domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR017281	Myeloid differentiation primary response protein MyD88	Family
K, L, M, N	IPR000719	Protein kinase domain	Domain
K, L, M, N	IPR042151	IRAK2, death domain	Domain
K, L, M, N	IPR011029	Death-like domain superfamily	Homologous Superfamily
K, L, M, N	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
K, L, M, N	IPR000488	Death domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
G, H, I, J	Pharos: Q9NWZ3	immunodeficiency 67 Invasive pneumococcal disease, recurrent isolated, 1 prostate cancer brain hypoxia - ischemia malignant mesothelioma systemic lupus erythematosus
A, B, C, D, E A, B, C, D, E, F	Pharos: Q99836	diffuse large B-cell lymphoma pyogenic bacterial infections due to MyD88 deficiency Waldenstrom macroglobulinemia follicular lymphoma pneumonia hypertensive disorder lymphoplasmacytic lymphoma Neoplasm Invasiveness macroglobulinemia extrahepatic cholestasis hypereosinophilic syndrome ischemia reperfusion injury lung cancer lymphoma arthritic joint disease diffuse large B-cell lymphoma pyogenic bacterial infections due to MyD88 deficiency Waldenstrom macroglobulinemia follicular lymphoma pneumonia hypertensive disorder lymphoplasmacytic lymphoma Neoplasm Invasiveness macroglobulinemia extrahepatic cholestasis hypereosinophilic syndrome ischemia reperfusion injury lung cancer lymphoma arthritic joint disease cancer macroglobulinemia, Waldenstrom, 1 congenital anemia multiple sclerosis ovarian cancer psoriasis glioblastoma subependymal giant cell astrocytoma juvenile dermatomyositis lung carcinoma astrocytic tumor malignant glioma cutaneous lupus erythematosus pancreatic intraductal papillary-mucinous neoplasm pneumonitis hematologic disease lymphatic system disease autoimmune disease colitis malignant mesothelioma pilocytic astrocytoma primitive neuroectodermal tumor
K, L, M, N	Pharos: O43187	cystic fibrosis malignant ependymoma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm tuberculosis large cell medulloblastoma malignant pancreatic neoplasm oligodendroglioma primitive neuroectodermal tumor ulcerative colitis lung adenocarcinoma medulloblastoma osteosarcoma psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.