3MN8

Structure of Drosophila melanogaster carboxypeptidase D isoform 1B short

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13620	e3mn8A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF13620	ECOD (1.6)
A	PF00246	e3mn8A1	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF00246	ECOD (1.6)
B	PF13620	e3mn8B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF13620	ECOD (1.6)
B	PF00246	e3mn8B2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF00246	ECOD (1.6)
C	PF13620	e3mn8C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF13620	ECOD (1.6)
C	PF00246	e3mn8C2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF00246	ECOD (1.6)
D	PF13620	e3mn8D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF13620	ECOD (1.6)
D	PF00246	e3mn8D2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF00246	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
A	2.60.40.1120	Mainly Beta	Sandwich	Immunoglobulin-like	Carboxypeptidase-like, regulatory domain	CATH (4.3.0)
B	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
B	2.60.40.1120	Mainly Beta	Sandwich	Immunoglobulin-like	Carboxypeptidase-like, regulatory domain	CATH (4.3.0)
C	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
C	2.60.40.1120	Mainly Beta	Sandwich	Immunoglobulin-like	Carboxypeptidase-like, regulatory domain	CATH (4.3.0)
D	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
D	2.60.40.1120	Mainly Beta	Sandwich	Immunoglobulin-like	Carboxypeptidase-like, regulatory domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF13620	Carboxypeptidase regulatory-like domain (CarboxypepD_reg)	Carboxypeptidase regulatory-like domain	-	Domain
A, B, C, D	PF00246	Zinc carboxypeptidase (Peptidase_M14)	Zinc carboxypeptidase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	LP15968p	peptidase activity catalytic activity, acting on a protein metallocarboxypeptidase activity hydrolase activity metallopeptidase activity exopeptidase activity catalytic activity metalloexopeptidase activity carboxypeptidase activity structural molecule activity structural constituent of cuticle cation binding transition metal ion binding zinc ion binding peptidase activity catalytic activity, acting on a protein metallocarboxypeptidase activity hydrolase activity metallopeptidase activity exopeptidase activity catalytic activity metalloexopeptidase activity carboxypeptidase activity structural molecule activity structural constituent of cuticle cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	behavior multicellular organismal process system process learning or memory long-term memory nervous system process cognition memory organic substance metabolic process metabolic process peptide metabolic process positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization behavior multicellular organismal process system process learning or memory long-term memory nervous system process cognition memory organic substance metabolic process metabolic process peptide metabolic process positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of actin filament-based process regulation of cellular component size positive regulation of biological process cellular component organization cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly positive regulation of protein polymerization protein-containing complex assembly actin filament-based process cellular component organization or biogenesis regulation of actin filament polymerization regulation of biological quality positive regulation of cellular process protein polymerization actin polymerization or depolymerization regulation of biological process regulation of actin filament organization actin filament polymerization actin cytoskeleton organization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization biological regulation actin filament organization regulation of actin polymerization or depolymerization positive regulation of supramolecular fiber organization regulation of cellular component biogenesis regulation of organelle organization organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process supramolecular fiber organization positive regulation of actin filament polymerization cytoskeleton organization regulation of anatomical structure size regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process developmental process imaginal disc morphogenesis appendage development post-embryonic appendage morphogenesis animal organ development wing disc development imaginal disc-derived wing morphogenesis instar larval or pupal development metamorphosis imaginal disc-derived appendage morphogenesis multicellular organism development anatomical structure morphogenesis wing disc morphogenesis appendage morphogenesis imaginal disc-derived appendage development imaginal disc development instar larval or pupal morphogenesis anatomical structure development post-embryonic animal morphogenesis post-embryonic development animal organ morphogenesis cellular biosynthetic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis organic substance biosynthetic process protein processing signaling receptor ligand precursor processing neuropeptide processing	cellular anatomical entity endomembrane system membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle extracellular region perinuclear region of cytoplasm extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR008969	Carboxypeptidase-like, regulatory domain superfamily	Homologous Superfamily
A, B, C, D	IPR000834	Peptidase M14, carboxypeptidase A	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.