3MKV

Crystal structure of amidohydrolase eaj56179

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad3mkva1 All beta proteins Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Ad3mkva2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Bd3mkvb1 All beta proteins Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Bd3mkvb2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Cd3mkvc1 All beta proteins Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Cd3mkvc2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Dd3mkvd1 All beta proteins Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Dd3mkvd2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Ed3mkve1 All beta proteins Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Ed3mkve2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Fd3mkvf1 All beta proteins Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Fd3mkvf2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Gd3mkvg1 All beta proteins Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Gd3mkvg2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Hd3mkvh1 All beta proteins Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)
Hd3mkvh2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Metallo-dependent hydrolases Zn-dependent arginine carboxypeptidase-like Uncharacterized protein EAJ56179 (unidentified ) [TaxId: 32644 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyZn-dependent arginine carboxypeptidase-like8024285 4001956 SCOP2 (2022-06-29)
ASCOP2 FamilyZn-dependent arginine carboxypeptidase-like8024288 4002032 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyMetallo-dependent hydrolases8036667 3000428 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMetallo-dependent hydrolases8036667 3000428 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMetallo-dependent hydrolases8036667 3000428 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyMetallo-dependent hydrolases8036667 3000428 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyMetallo-dependent hydrolases8036667 3000428 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyMetallo-dependent hydrolases8036667 3000428 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyMetallo-dependent hydrolases8036667 3000428 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyMetallo-dependent hydrolases8036667 3000428 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases8036664 3000176 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AF_UNCLASSIFIEDe3mkvA4 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: F_UNCLASSIFIEDECOD (1.6)
APF01979e3mkvA3 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PF01979ECOD (1.6)
BF_UNCLASSIFIEDe3mkvB6 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: F_UNCLASSIFIEDECOD (1.6)
BPF01979e3mkvB5 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PF01979ECOD (1.6)
CF_UNCLASSIFIEDe3mkvC6 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: F_UNCLASSIFIEDECOD (1.6)
CPF01979e3mkvC5 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PF01979ECOD (1.6)
DF_UNCLASSIFIEDe3mkvD6 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: F_UNCLASSIFIEDECOD (1.6)
DPF01979e3mkvD5 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PF01979ECOD (1.6)
EF_UNCLASSIFIEDe3mkvE6 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: F_UNCLASSIFIEDECOD (1.6)
EPF01979e3mkvE5 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PF01979ECOD (1.6)
FF_UNCLASSIFIEDe3mkvF6 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: F_UNCLASSIFIEDECOD (1.6)
FPF01979e3mkvF5 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PF01979ECOD (1.6)
GF_UNCLASSIFIEDe3mkvG6 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: F_UNCLASSIFIEDECOD (1.6)
GPF01979e3mkvG5 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PF01979ECOD (1.6)
HF_UNCLASSIFIEDe3mkvH6 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: F_UNCLASSIFIEDECOD (1.6)
HPF01979e3mkvH5 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PF01979ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
A3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)
B2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
B3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)
C2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
C3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)
D2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
D3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)
E2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
E3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)
F2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
F3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)
G2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
G3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)
H2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
H3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF01979Amidohydrolase family (Amidohydro_1)Amidohydrolase familyThis family of enzymes are a a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisatio ...This family of enzymes are a a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
PUTATIVE AMIDOHYDROLASE - -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR006680Amidohydrolase-relatedDomain
A, B, C, D, E
IPR011059Metal-dependent hydrolase, composite domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR032466Metal-dependent hydrolaseHomologous Superfamily