Annotations: 3MCB

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01849	e3mcbA1	A: beta sandwiches	X: Nascent polypeptide-associated complex (NAC) dimerization domain (From Topology)	H: Nascent polypeptide-associated complex (NAC) dimerization domain (From Topology)	T: Nascent polypeptide-associated complex (NAC) dimerization domain	F: PF01849	ECOD (1.6)
B	PF01849	e3mcbB1	A: beta sandwiches	X: Nascent polypeptide-associated complex (NAC) dimerization domain (From Topology)	H: Nascent polypeptide-associated complex (NAC) dimerization domain (From Topology)	T: Nascent polypeptide-associated complex (NAC) dimerization domain	F: PF01849	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.20.70.30	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4	Chain: W	CATH (4.3.0)
B	2.20.70.30	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4	Chain: W	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01849	NAC domain (NAC)	NAC domain	-	Family
B	PF01849	NAC domain (NAC)	NAC domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Nascent polypeptide-associated complex subunit alpha	DNA binding binding organic cyclic compound binding nucleic acid binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	developmental process heart development multicellular organism development multicellular organismal process cardiac chamber development anatomical structure development animal organ development cardiac ventricle development circulatory system development system development regulation of biological process regulation of cellular process muscle cell apoptotic process negative regulation of programmed cell death developmental process heart development multicellular organism development multicellular organismal process cardiac chamber development anatomical structure development animal organ development cardiac ventricle development circulatory system development system development regulation of biological process regulation of cellular process muscle cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of muscle cell apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process negative regulation of muscle cell apoptotic process negative regulation of cellular process negative regulation of striated muscle cell apoptotic process cellular process apoptotic process programmed cell death positive regulation of cell population proliferation positive regulation of cell proliferation involved in heart morphogenesis heart morphogenesis positive regulation of biological process animal organ morphogenesis positive regulation of cellular process cell population proliferation anatomical structure morphogenesis cell proliferation involved in heart morphogenesis regulation of cell population proliferation regulation of cell proliferation involved in heart morphogenesis regulation of muscle tissue development regulation of growth regulation of developmental process developmental growth skeletal muscle tissue development positive regulation of skeletal muscle tissue development regulation of skeletal muscle tissue development muscle structure development positive regulation of developmental process skeletal muscle organ development regulation of skeletal muscle tissue growth positive regulation of skeletal muscle tissue growth muscle tissue development muscle organ development positive regulation of developmental growth regulation of developmental growth growth tissue development positive regulation of growth positive regulation of muscle tissue development skeletal muscle tissue growth wound healing response to stimulus response to stress response to wounding protein localization regulation of localization cellular localization regulation of protein localization negative regulation of protein localization to endoplasmic reticulum localization regulation of protein localization to endoplasmic reticulum regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to endoplasmic reticulum negative regulation of protein localization tissue regeneration skeletal muscle tissue regeneration regeneration establishment of protein localization nitrogen compound transport transport organic substance transport establishment of localization protein transport heart trabecula morphogenesis trabecula morphogenesis negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular developmental process cell development regulation of cell differentiation regulation of striated muscle cell differentiation muscle cell differentiation myotube differentiation regulation of cell development regulation of skeletal muscle fiber development muscle cell development cell differentiation regulation of myotube differentiation myotube cell development skeletal muscle fiber development regulation of muscle cell differentiation striated muscle cell differentiation organonitrogen compound metabolic process organonitrogen compound biosynthetic process translation protein metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm nascent polypeptide-associated complex protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm nascent polypeptide-associated complex protein-containing complex intracellular organelle nucleus intracellular membrane-bounded organelle
B	Transcription factor BTF3	RNA binding binding organic cyclic compound binding nucleic acid binding	developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization negative regulation of protein localization to endoplasmic reticulum biological regulation negative regulation of biological process localization regulation of protein localization to endoplasmic reticulum regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle negative regulation of cellular process cellular process protein localization to endoplasmic reticulum negative regulation of protein localization establishment of protein localization nitrogen compound transport transport organic substance transport establishment of localization protein transport	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol nascent polypeptide-associated complex protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038187	NAC A/B domain superfamily	Homologous Superfamily
A	IPR044034	Nascent polypeptide-associated complex subunit alpha-like, UBA domain	Domain
A	IPR016641	Nascent polypeptide-associated complex subunit alpha-like	Family
A	IPR002715	Nascent polypeptide-associated complex NAC domain	Domain
B	IPR039370	Transcription factor BTF3	Family
B	IPR038187	NAC A/B domain superfamily	Homologous Superfamily
B	IPR002715	Nascent polypeptide-associated complex NAC domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13765	atrial fibrillation adrenal cortex carcinoma lung cancer malignant mesothelioma ovarian cancer lymphoplasmacytic lymphoma myopathy pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma malignant colon neoplasm osteosarcoma plasma cell myeloma
B	Pharos: P20290	breast cancer medulloblastoma large cell medulloblastoma ovarian cancer lymphoplasmacytic lymphoma plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.