3M9I

Electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) in E. coli polar lipids

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3m9ia_	Membrane and cell surface proteins and peptides	Aquaporin-like	Aquaporin-like	automated matches	automated matches	(Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Aquaporin-like	8037743	3000508	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MIP	e3m9iA1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1080.10	Mainly Alpha	Up-down Bundle	Glycerol uptake facilitator protein	Glycerol uptake facilitator protein.	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00230	Major intrinsic protein (MIP)	Major intrinsic protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Lens fiber major intrinsic protein	structural molecule activity structural constituent of eye lens protein binding binding calmodulin binding passive transmembrane transporter activity water transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity transporter activity transmembrane transporter activity water channel activity	regulation of biological process cell adhesion regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process cellular process positive regulation of cellular process developmental process multicellular organismal process sensory organ development eye development animal organ development regulation of biological process cell adhesion regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process cellular process positive regulation of cellular process developmental process multicellular organismal process sensory organ development eye development animal organ development visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development lens development in camera-type eye system development sensory perception of light stimulus system process sensory perception nervous system process visual perception protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis gap junction-mediated intercellular transport localization intercellular transport transport establishment of localization fluid transport water transport response to stimulus	cell-cell junction anchoring junction gap junction cell junction cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum cytoplasm cell-cell junction anchoring junction gap junction cell junction cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR034294	Aquaporin transporter	Family
A	IPR022357	Major intrinsic protein, conserved site	Conserved Site
A	IPR023271	Aquaporin-like	Homologous Superfamily
A	IPR000425	Major intrinsic protein	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	Major Intrinsic Protein (MIP)/FNT superfamily	Major intrinsic protein (MIP) family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.