3M3E

Crystal Structure of Agrocybe aegerita lectin AAL mutant E66A complexed with p-Nitrophenyl Thomsen-Friedenreich disaccharide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3m3ea1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)
A	d3m3ea2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)
B	d3m3eb1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)
B	d3m3eb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)
C	d3m3ec1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)
C	d3m3ec3	Artifacts	Tags	Tags	Tags	C-terminal Tags	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)
C	d3m3ec2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)
D	d3m3ed1	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)
D	d3m3ed3	Artifacts	Tags	Tags	Tags	C-terminal Tags	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)
D	d3m3ed2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Black poplar mushroom (Cyclocybe aegerita ) [TaxId: 1973307 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8089060	3000120	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8089060	3000120	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8089060	3000120	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8089060	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Gal-bind_lectin	e3m3eA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)
B	Gal-bind_lectin	e3m3eB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)
C	Gal-bind_lectin	e3m3eC1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)
D	Gal-bind_lectin	e3m3eD1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Gal-bind_lectin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
B	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
C	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
D	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00337	Galactoside-binding lectin (Gal-bind_lectin)	Galactoside-binding lectin	This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Anti-tumor lectin	catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity binding polysaccharide binding carbohydrate binding	cellular process apoptotic process cell death programmed cell death regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C, D	IPR001079	Galectin, carbohydrate recognition domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.