3LUI

Crystal structure of the SNX17 PX domain with bound sulphate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3luib_	Alpha and beta proteins (a+b)	PX domain	PX domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3luia_	Alpha and beta proteins (a+b)	PX domain	PX domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3luic1	Alpha and beta proteins (a+b)	PX domain	PX domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3luic2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PX	e3luiB1	A: a+b two layers	X: PX domain (From Topology)	H: PX domain (From Topology)	T: PX domain	F: PX	ECOD (1.6)
A	PX	e3luiA2	A: a+b two layers	X: PX domain (From Topology)	H: PX domain (From Topology)	T: PX domain	F: PX	ECOD (1.6)
C	PX	e3luiC1	A: a+b two layers	X: PX domain (From Topology)	H: PX domain (From Topology)	T: PX domain	F: PX	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.1520.10	Alpha Beta	2-Layer Sandwich	PX Domain	Phox-like domain	CATH (4.3.0)
A	3.30.1520.10	Alpha Beta	2-Layer Sandwich	PX Domain	Phox-like domain	CATH (4.3.0)
C	3.30.1520.10	Alpha Beta	2-Layer Sandwich	PX Domain	Phox-like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00787	PX domain (PX)	PX domain	PX domains bind to phosphoinositides.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Sorting nexin-17	binding phospholipid binding lipid binding phosphatidylinositol binding protein binding signaling receptor binding low-density lipoprotein particle receptor binding lipoprotein particle receptor binding	sterol catabolic process alcohol catabolic process catabolic process lipid catabolic process organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process alcohol metabolic process primary metabolic process organic cyclic compound catabolic process cholesterol catabolic process organic cyclic compound metabolic process secondary alcohol metabolic process organic substance metabolic process sterol catabolic process alcohol catabolic process catabolic process lipid catabolic process organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process alcohol metabolic process primary metabolic process organic cyclic compound catabolic process cholesterol catabolic process organic cyclic compound metabolic process secondary alcohol metabolic process organic substance metabolic process steroid catabolic process organic hydroxy compound catabolic process metabolic process small molecule metabolic process small molecule catabolic process organic substance catabolic process lipid metabolic process developmental process heart development multicellular organism development multicellular organismal process cardiac septum development cardiac chamber development anatomical structure development animal organ development circulatory system development system development regulation of localization import into cell regulation of biological process regulation of cellular process regulation of cellular component organization regulation of transport transport biological regulation regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport cellular component organization localization cellular process cellular component organization or biogenesis endocytosis regulation of endocytosis artery development aorta development vasculature development blood vessel development cellular response to stimulus response to stimulus signaling signal transduction cell communication protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport endosomal transport coronary vasculature development kidney development renal system development localization within membrane endocytic recycling vesicle-mediated transport to the plasma membrane receptor-mediated endocytosis	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle protein-containing complex cytoplasmic vesicle intracellular vesicle vesicle early endosome membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle protein-containing complex cytoplasmic vesicle intracellular vesicle vesicle early endosome endosome endomembrane system Golgi apparatus endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR001683	Phox homology	Domain
A, B, C	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B, C	IPR037836	SNX17, atypical FERM-like domain	Domain
A, B, C	IPR048763	Sortin nexin 17/31, FERM domain, F1 lobe	Domain
A, B, C	IPR000159	Ras-associating domain	Domain
A, B, C	IPR037831	SNX17/27/31-like	Family
A, B, C	IPR028666	Sorting nexin-17, FERM domain, N-terminal subdomain	Domain
A, B, C	IPR040842	Sorting nexin-17/31, FERM domain	Domain
A, B, C	IPR036871	PX domain superfamily	Homologous Superfamily
A, B, C	IPR048767	Sortin nexin 17/31, FERM domain, F2 lobe	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q15036	Crohn disease ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.