3LRH

Structure of anti-huntingtin VL domain in complex with huntingtin peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
O	d3lrho_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	V-set_3	e3lrhA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
C	V-set_3	e3lrhC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
E	V-set_3	e3lrhE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
G	V-set_3	e3lrhG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
I	V-set_3	e3lrhI1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
K	V-set_3	e3lrhK1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
M	V-set_3	e3lrhM1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
O	V-set_3	e3lrhO1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
I	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
K	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
M	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
O	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, C, E, G, I A, C, E, G, I, K, M, O	Human light chain V-LAMBDA, anti-huntingtin, G112>A	V-LAMBDA	Homo sapiens (human)	IGLV1-3601, IGLJ302	V-DOMAIN V-LAMBDA	IG	(V-LAMBDA)	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A, C, E, G, I A, C, E, G, I, K, M, O	Light Chain	IGLV1	Lambda	huntingtin	SAbDab (2024-04-19)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M, O	anti-huntingtin VL domain	-	-	-
B, D, F, H, J B, D, F, H, J, L, N, P	Huntingtin	protein binding binding heat shock protein binding cytoskeletal protein binding dynactin binding dynein intermediate chain binding identical protein binding p53 binding profilin binding kinase binding enzyme binding transmembrane transporter binding beta-tubulin binding tubulin binding	multicellular organismal process system process learning or memory learning nervous system process imitative learning auditory behavior response to stimulus vocal learning learned vocalization behavior or vocal learning response to mechanical stimulus cognition response to external stimulus mechanosensory behavior behavior multicellular organismal process system process learning or memory learning nervous system process imitative learning auditory behavior response to stimulus vocal learning learned vocalization behavior or vocal learning response to mechanical stimulus cognition response to external stimulus mechanosensory behavior behavior response to auditory stimulus observational learning response to abiotic stimulus protein destabilization regulation of protein stability biological regulation regulation of biological quality localization transport microtubule-based transport establishment of localization cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process signaling regulation of signal transduction calmodulin dependent kinase signaling pathway intracellular signal transduction cell communication regulation of CAMKK-AMPK signaling cascade calcium-mediated signaling regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of calcium-mediated signaling regulation of cell communication cellular process signal transduction CAMKK-AMPK signaling cascade apoptotic process cell death programmed cell death positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process regulation of calcium ion transmembrane transporter activity positive regulation of cell communication regulation of localization regulation of calcium ion transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport positive regulation of signal transduction intracellular calcium ion homeostasis negative regulation of biological process regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity calcium ion transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of cation channel activity positive regulation of cation channel activity inorganic cation transmembrane transport maintenance of location transmembrane transport regulation of molecular function release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis cellular localization inorganic ion homeostasis homeostatic process monoatomic ion transmembrane transport regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport regulation of transporter activity maintenance of location in cell monoatomic cation transmembrane transport regulation of calcium ion transmembrane transport positive regulation of response to stimulus positive regulation of molecular function positive regulation of calcium ion transmembrane transporter activity intracellular monoatomic cation homeostasis positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport monoatomic ion homeostasis negative regulation of cellular process monoatomic ion transport intracellular chemical homeostasis positive regulation of release of sequestered calcium ion into cytosol regulation of metal ion transport regulation of sequestering of calcium ion regulation of monoatomic ion transmembrane transporter activity calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity cellular homeostasis positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport positive regulation of signaling retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Golgi vesicle transport vesicle-mediated transport establishment of organelle localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle cellular component organization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle cellular component organization or biogenesis microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of cell polarity organelle organization mitotic cell cycle process establishment of mitotic spindle orientation microtubule-based process cytoskeleton organization regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of transferase activity regulation of primary metabolic process organic substance metabolic process regulation of phosphate metabolic process regulation of cAMP-dependent protein kinase activity phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of signaling extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of apoptotic signaling pathway vesicle cytoskeletal trafficking vesicle localization organelle transport along microtubule establishment of vesicle localization intracellular transport vesicle transport along microtubule transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement catabolic process lipophagy macroautophagy autophagy positive regulation of cellular metabolic process regulation of autophagy cellular catabolic process positive regulation of metabolic process positive regulation of lipophagy regulation of lipophagy positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of autophagy regulation of catabolic process positive regulation of catabolic process regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of aggrephagy aggrephagy regulation of aggrephagy protein dephosphorylation regulation of phosphatase activity regulation of phosphoprotein phosphatase activity regulation of dephosphorylation regulation of protein dephosphorylation dephosphorylation regulation of hydrolase activity positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly positive regulation of cell projection organization cilium organization plasma membrane bounded cell projection organization organelle assembly positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of cellular component biogenesis regulation of organelle organization regulation of plasma membrane bounded cell projection assembly positive regulation of cilium assembly regulation of cilium assembly regulation of organelle assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly positive regulation of organelle assembly positive regulation of autophagy of mitochondrion mitophagy organelle disassembly regulation of autophagy of mitochondrion mitochondrion organization cellular component disassembly positive regulation of mitophagy regulation of mitophagy regulation of mitochondrion organization autophagy of mitochondrion Golgi organization endomembrane system organization	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection inclusion body membrane-bounded organelle intracellular organelle organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection inclusion body membrane-bounded organelle intracellular organelle organelle vacuole autophagosome intracellular membrane-bounded organelle Golgi apparatus endomembrane system perinuclear region of cytoplasm axon microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle centriole microtubule cytoskeleton non-membrane-bounded organelle cytosolic region presynapse presynaptic cytosol synapse cell junction nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex membrane intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle organelle membrane early endosome endosome late endosome endoplasmic reticulum postsynapse postsynaptic cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D, F, H, J B, D, F, H, J, L, N, P	IPR016024	Armadillo-type fold	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR048412	Huntingtin, bridge	Repeat
B, D, F, H, J B, D, F, H, J, L, N, P	IPR048411	Huntingtin, N-terminal, HEAT repeats 1	Repeat
B, D, F, H, J B, D, F, H, J, L, N, P	IPR000091	Huntingtin	Family
B, D, F, H, J B, D, F, H, J, L, N, P	IPR011989	Armadillo-like helical	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR028426	Huntingtin family	Family
B, D, F, H, J B, D, F, H, J, L, N, P	IPR024613	Huntingtin, N-terminal, HEAT repeats 2	Repeat
B, D, F, H, J B, D, F, H, J, L, N, P	IPR048413	Huntingtin, C-terminal HEAT repeats	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D, F, H, J B, D, F, H, J, L, N, P	Pharos: P42858	Huntington disease manganese poisoning cadmium poisoning Lopes-Maciel-Rodan syndrome neurodegenerative disease toxic encephalopathy Akinetic-Rigid Variant of Huntington Disease dementia intellectual disability movement disorder Parkinson disease brain disease depressive disorder juvenile Huntington disease psoriasis Huntington disease manganese poisoning cadmium poisoning Lopes-Maciel-Rodan syndrome neurodegenerative disease toxic encephalopathy Akinetic-Rigid Variant of Huntington Disease dementia intellectual disability movement disorder Parkinson disease brain disease depressive disorder juvenile Huntington disease psoriasis endogenous depression

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.