3LLO

Crystal structure of the STAS domain of motor protein prestin (anion transporter SLC26A5)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SLC26 transporter cytoplasmic STAS domain-like	8101732	4007785	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SpoIIaa-like	8101733	3001065	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	STAS_1	e3lloA1	A: a/b three-layered sandwiches	X: SpoIIaa-like (From Topology)	H: SpoIIaa-like (From Topology)	T: SpoIIaa-like	F: STAS_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.750.24	Alpha Beta	2-Layer Sandwich	Transcription Regulator spoIIAA	STAS domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01740	STAS domain (STAS)	STAS domain	The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding ...	The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Prestin	cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding cytoskeletal motor activity bicarbonate transmembrane transporter activity transporter activity transmembrane transporter activity organic anion transmembrane transporter activity oxalate transmembrane transporter activity dicarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding cytoskeletal motor activity bicarbonate transmembrane transporter activity transporter activity transmembrane transporter activity organic anion transmembrane transporter activity oxalate transmembrane transporter activity dicarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity chloride transmembrane transporter activity monoatomic anion transmembrane transporter activity bicarbonate:monoatomic anion antiporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity chloride:bicarbonate antiporter activity monoatomic ion transmembrane transporter activity inorganic anion transmembrane transporter activity solute:inorganic anion antiporter activity sulfate transmembrane transporter activity sulfur compound transmembrane transporter activity identical protein binding protein homodimerization activity protein dimerization activity secondary active sulfate transmembrane transporter activity	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development response to stimulus response to chemical response to xenobiotic stimulus regulation of localization regulation of biological process regulation of cellular process transport developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development response to stimulus response to chemical response to xenobiotic stimulus regulation of localization regulation of biological process regulation of cellular process transport regulation of transport negative regulation of monoatomic ion transport regulation of monoatomic ion transport monoatomic ion transmembrane transport biological regulation negative regulation of biological process negative regulation of transport regulation of monoatomic ion transmembrane transport establishment of localization negative regulation of transmembrane transport transmembrane transport localization regulation of transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport cellular process organic acid transport organic anion transport carboxylic acid transport oxalate transport organic substance transport dicarboxylic acid transport inorganic ion transmembrane transport inorganic anion transmembrane transport chloride transport chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport inorganic anion transport response to stress response to ischemia bicarbonate transport response to potassium ion response to metal ion response to inorganic substance response to organic substance response to oxygen-containing compound response to salicylic acid response to organic cyclic compound regulation of developmental process regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis regulation of biological quality regulation of anatomical structure morphogenesis response to auditory stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus response to salt regulation of membrane potential response to thyroid hormone response to hormone response to endogenous stimulus hexose transmembrane transport carbohydrate transport fructose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport multicellular organismal process system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus positive regulation of cell size cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of cell size regulation of anatomical structure size positive regulation of locomotion regulation of cell motility positive regulation of biological process regulation of locomotion positive regulation of cell motility cell motility positive regulation of cellular process locomotion	lateral wall of outer hair cell lateral part of cell cellular anatomical entity cell periphery plasma membrane membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane lateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001902	SLC26A/SulP transporter	Family
A	IPR002645	STAS domain	Domain
A	IPR018045	Sulphate anion transporter, conserved site	Conserved Site
A	IPR036513	STAS domain superfamily	Homologous Superfamily
A	IPR011547	SLC26A/SulP transporter domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	APC (Amino acid-Polyamine-organoCation) superfamily	Sulfate permease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.