3LIE

Crystal Structure of the extracellular domain of the putative histidine kinase vpHK1S-Z8

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3liea2	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	YkuI C-terminal domain-like	GGDEF family protein VP0354, C-terminal domain	(Vibrio parahaemolyticus ) [TaxId: 670 ],	SCOPe (2.08)
A	d3liea1	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	YkuI C-terminal domain-like	GGDEF family protein VP0354, N-terminal domain	(Vibrio parahaemolyticus ) [TaxId: 670 ],	SCOPe (2.08)
B	d3lieb2	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	YkuI C-terminal domain-like	GGDEF family protein VP0354, C-terminal domain	(Vibrio parahaemolyticus ) [TaxId: 670 ],	SCOPe (2.08)
B	d3lieb1	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	YkuI C-terminal domain-like	GGDEF family protein VP0354, N-terminal domain	(Vibrio parahaemolyticus ) [TaxId: 670 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sensory domain-like	8035449	3001802	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Sensory domain-like	8035447	3001802	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sensory domain-like	8035447	3001802	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sensory domain-like	8035449	3001802	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3lieA2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF21623	e3lieA1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PF21623	ECOD (1.6)
B	F_UNCLASSIFIED	e3lieB2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF21623	e3lieB1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PF21623	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
B	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21623	Bacterial histidine kinase, sensor domain (HK_sensor_dom_bact)	Bacterial histidine kinase, sensor domain	This sensor domain is found in Histidine kinase from Vibrio parahaemolyticus. This domain shows an alpha-beta structure [1]. It is found associated with Pfam:PF13426 and Pfam:PF00990.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Putative sensory box/GGDEF family protein	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR035965	PAS domain superfamily	Homologous Superfamily
A, B	IPR048760	Histidine kinase VP0354-like, sensor domain	Domain
A, B	IPR000700	PAS-associated, C-terminal	Domain
A, B	IPR000014	PAS domain	Domain
A, B	IPR000160	GGDEF domain	Domain
A, B	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
A, B	IPR029151	Periplasmic sensor-like domain superfamily	Homologous Superfamily
A, B	IPR029787	Nucleotide cyclase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.